Alpha-synuclein misfolding as fluid biomarker for Parkinson’s disease measured with the iRS platform

Alpha-synuclein misfolding as fluid biomarker for Parkinson’s disease measured with the iRS platform

Abstract Misfolding and aggregation of alpha-synuclein (αSyn) play a key role in the pathophysiology of Parkinson’s disease (PD). Despite considerable advances in diagnostics, an early and differential diagnosis of PD still represents a major challenge. We innovated the immuno-infrared sensor (iRS)...

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Main Authors: Martin Schuler, Grischa Gerwert, Marvin Mann, Nathalie Woitzik, Lennart Langenhoff, Diana Hubert, Deniz Duman, Adrian Höveler, Sandy Galkowski, Jonas Simon, Robin Denz, Sandrina Weber, Eun-Hae Kwon, Robin Wanka, Carsten Kötting, Jörn Güldenhaupt, Léon Beyer, Lars Tönges, Brit Mollenhauer, Klaus Gerwert
Format: Article
Language:English
Published: Springer Nature 2025-04-01
Series:EMBO Molecular Medicine
Subjects:
Parkinson’s Disease Diagnosis
Alpha-synuclein in CSF
Protein Misfolding
Immuno-infrared-sensor
Differential Diagnosis
Online Access:https://doi.org/10.1038/s44321-025-00229-z
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