Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients
Abstract The COVID-19 pandemic has been the largest pandemic of the past century, and various genetic factors have played a significant role in this context. This study aimed to analyze the frequency and association between specific SNPs rs3806268 (NLRP3), rs4925543 (NLRP3), rs12150220 (NLRP1), rs45...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Ciências
2024-11-01
|
| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652024000700702&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846156340756480000 |
|---|---|
| author | PABLO C.S. FARIAS LEANDRO P. CABRAL PATRÍCIA A.F. NEVES CAIO A.B. JANUÁRIO BEATRIZ M. CORDEIRO WILSON J. DA SILVA JÚNIOR CAROLINA BASEGGIO SÉRGIO S.L. PAIVA JÚNIOR PAULO S.R. DE ARAÚJO VIRGÍNIA MARIA B. DE LORENA VALDIR Q. BALBINO REGINALDO G. LIMA NETO |
| author_facet | PABLO C.S. FARIAS LEANDRO P. CABRAL PATRÍCIA A.F. NEVES CAIO A.B. JANUÁRIO BEATRIZ M. CORDEIRO WILSON J. DA SILVA JÚNIOR CAROLINA BASEGGIO SÉRGIO S.L. PAIVA JÚNIOR PAULO S.R. DE ARAÚJO VIRGÍNIA MARIA B. DE LORENA VALDIR Q. BALBINO REGINALDO G. LIMA NETO |
| author_sort | PABLO C.S. FARIAS |
| collection | DOAJ |
| description | Abstract The COVID-19 pandemic has been the largest pandemic of the past century, and various genetic factors have played a significant role in this context. This study aimed to analyze the frequency and association between specific SNPs rs3806268 (NLRP3), rs4925543 (NLRP3), rs12150220 (NLRP1), rs455060 (NLRC4), rs699 (AGT), rs1137101 (LEPR), and rs1801133 (MTHFR) and severe/critical outcomes in Brazilian patients with COVID-19. A total of 100 patients were included in the study, comprising 66 cases and 34 controls. DNA was extracted, sequenced, and genotyped via next-generation sequencing (NGS). For non-parametric data, the Mann-Whitney and Kruskal-Wallis tests were used. Fisher’s test and multivariate logistic regression, considering AIC and BIC criteria, were employed for risk analysis. Odds Ratios (OR) were calculated, with significance set at p<0.05. Among the seven evaluated SNPs, only rs699-GG (AGT) (OR=8.07; p=0.04) was significantly associated with an increased risk of developing severe/critical COVID-19. Moreover, a borderline protective association was noted between rs1801133-GA (MTHFR) and the disease, although lacking statistical significance. In conclusion, the SNP rs699-GG (AGT) was associated with an increased risk of severe/critical COVID-19. |
| format | Article |
| id | doaj-art-bb6a936e0b5c4803a29b3057653e21b9 |
| institution | Kabale University |
| issn | 1678-2690 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj-art-bb6a936e0b5c4803a29b3057653e21b92024-11-26T07:46:19ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902024-11-0196suppl 310.1590/0001-3765202420240274Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patientsPABLO C.S. FARIAShttps://orcid.org/0000-0001-8734-3468LEANDRO P. CABRALhttps://orcid.org/0000-0002-4094-1345PATRÍCIA A.F. NEVEShttps://orcid.org/0009-0005-8152-3827CAIO A.B. JANUÁRIOhttps://orcid.org/0000-0002-8916-9165BEATRIZ M. CORDEIROhttps://orcid.org/0009-0008-5089-319XWILSON J. DA SILVA JÚNIORhttps://orcid.org/0000-0002-0217-7665CAROLINA BASEGGIOhttps://orcid.org/0009-0002-1958-7043SÉRGIO S.L. PAIVA JÚNIORhttps://orcid.org/0000-0002-9938-6673PAULO S.R. DE ARAÚJOhttps://orcid.org/0000-0002-7839-0737VIRGÍNIA MARIA B. DE LORENAhttps://orcid.org/0000-0003-0663-236XVALDIR Q. BALBINOhttps://orcid.org/0000-0002-4319-3952REGINALDO G. LIMA NETOhttps://orcid.org/0000-0002-8846-877XAbstract The COVID-19 pandemic has been the largest pandemic of the past century, and various genetic factors have played a significant role in this context. This study aimed to analyze the frequency and association between specific SNPs rs3806268 (NLRP3), rs4925543 (NLRP3), rs12150220 (NLRP1), rs455060 (NLRC4), rs699 (AGT), rs1137101 (LEPR), and rs1801133 (MTHFR) and severe/critical outcomes in Brazilian patients with COVID-19. A total of 100 patients were included in the study, comprising 66 cases and 34 controls. DNA was extracted, sequenced, and genotyped via next-generation sequencing (NGS). For non-parametric data, the Mann-Whitney and Kruskal-Wallis tests were used. Fisher’s test and multivariate logistic regression, considering AIC and BIC criteria, were employed for risk analysis. Odds Ratios (OR) were calculated, with significance set at p<0.05. Among the seven evaluated SNPs, only rs699-GG (AGT) (OR=8.07; p=0.04) was significantly associated with an increased risk of developing severe/critical COVID-19. Moreover, a borderline protective association was noted between rs1801133-GA (MTHFR) and the disease, although lacking statistical significance. In conclusion, the SNP rs699-GG (AGT) was associated with an increased risk of severe/critical COVID-19.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652024000700702&lng=en&tlng=enAGT geneCOVID-19human geneticsSARS-CoV-2SNPs |
| spellingShingle | PABLO C.S. FARIAS LEANDRO P. CABRAL PATRÍCIA A.F. NEVES CAIO A.B. JANUÁRIO BEATRIZ M. CORDEIRO WILSON J. DA SILVA JÚNIOR CAROLINA BASEGGIO SÉRGIO S.L. PAIVA JÚNIOR PAULO S.R. DE ARAÚJO VIRGÍNIA MARIA B. DE LORENA VALDIR Q. BALBINO REGINALDO G. LIMA NETO Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients Anais da Academia Brasileira de Ciências AGT gene COVID-19 human genetics SARS-CoV-2 SNPs |
| title | Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients |
| title_full | Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients |
| title_fullStr | Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients |
| title_full_unstemmed | Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients |
| title_short | Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients |
| title_sort | genetic variant in the agt gene rs699 gg is associated with severe covid 19 in brazilian patients |
| topic | AGT gene COVID-19 human genetics SARS-CoV-2 SNPs |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652024000700702&lng=en&tlng=en |
| work_keys_str_mv | AT pablocsfarias geneticvariantintheagtgeners699ggisassociatedwithseverecovid19inbrazilianpatients AT leandropcabral geneticvariantintheagtgeners699ggisassociatedwithseverecovid19inbrazilianpatients AT patriciaafneves geneticvariantintheagtgeners699ggisassociatedwithseverecovid19inbrazilianpatients AT caioabjanuario geneticvariantintheagtgeners699ggisassociatedwithseverecovid19inbrazilianpatients AT beatrizmcordeiro geneticvariantintheagtgeners699ggisassociatedwithseverecovid19inbrazilianpatients AT wilsonjdasilvajunior geneticvariantintheagtgeners699ggisassociatedwithseverecovid19inbrazilianpatients AT carolinabaseggio geneticvariantintheagtgeners699ggisassociatedwithseverecovid19inbrazilianpatients AT sergioslpaivajunior geneticvariantintheagtgeners699ggisassociatedwithseverecovid19inbrazilianpatients AT paulosrdearaujo geneticvariantintheagtgeners699ggisassociatedwithseverecovid19inbrazilianpatients AT virginiamariabdelorena geneticvariantintheagtgeners699ggisassociatedwithseverecovid19inbrazilianpatients AT valdirqbalbino geneticvariantintheagtgeners699ggisassociatedwithseverecovid19inbrazilianpatients AT reginaldoglimaneto geneticvariantintheagtgeners699ggisassociatedwithseverecovid19inbrazilianpatients |