Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients

Genetic variant in the AGT gene (rs699-GG) is associated with severe COVID-19 in Brazilian patients

Abstract The COVID-19 pandemic has been the largest pandemic of the past century, and various genetic factors have played a significant role in this context. This study aimed to analyze the frequency and association between specific SNPs rs3806268 (NLRP3), rs4925543 (NLRP3), rs12150220 (NLRP1), rs45...

Full description

Saved in:
Bibliographic Details
Main Authors: PABLO C.S. FARIAS, LEANDRO P. CABRAL, PATRÍCIA A.F. NEVES, CAIO A.B. JANUÁRIO, BEATRIZ M. CORDEIRO, WILSON J. DA SILVA JÚNIOR, CAROLINA BASEGGIO, SÉRGIO S.L. PAIVA JÚNIOR, PAULO S.R. DE ARAÚJO, VIRGÍNIA MARIA B. DE LORENA, VALDIR Q. BALBINO, REGINALDO G. LIMA NETO
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2024-11-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
AGT gene
COVID-19
human genetics
SARS-CoV-2
SNPs
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652024000700702&lng=en&tlng=en
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The COVID-19 pandemic has been the largest pandemic of the past century, and various genetic factors have played a significant role in this context. This study aimed to analyze the frequency and association between specific SNPs rs3806268 (NLRP3), rs4925543 (NLRP3), rs12150220 (NLRP1), rs455060 (NLRC4), rs699 (AGT), rs1137101 (LEPR), and rs1801133 (MTHFR) and severe/critical outcomes in Brazilian patients with COVID-19. A total of 100 patients were included in the study, comprising 66 cases and 34 controls. DNA was extracted, sequenced, and genotyped via next-generation sequencing (NGS). For non-parametric data, the Mann-Whitney and Kruskal-Wallis tests were used. Fisher’s test and multivariate logistic regression, considering AIC and BIC criteria, were employed for risk analysis. Odds Ratios (OR) were calculated, with significance set at p<0.05. Among the seven evaluated SNPs, only rs699-GG (AGT) (OR=8.07; p=0.04) was significantly associated with an increased risk of developing severe/critical COVID-19. Moreover, a borderline protective association was noted between rs1801133-GA (MTHFR) and the disease, although lacking statistical significance. In conclusion, the SNP rs699-GG (AGT) was associated with an increased risk of severe/critical COVID-19.
ISSN:1678-2690

Similar Items