Human adipose‐derived multipotent stromal cells enriched with IL‐10 modRNA improve diabetic wound healing: Trigger the macrophage phenotype shift

Human adipose‐derived multipotent stromal cells enriched with IL‐10 modRNA improve diabetic wound healing: Trigger the macrophage phenotype shift

Abstract Diabetic wounds present a significant challenge in regenerative medicine due to impaired healing, characterized by prolonged inflammation and deficient tissue repair, primarily caused by a skewed pro‐inflammatory macrophage phenotype. This study investigates the therapeutic potential of int...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yuxin Zhang, Wei Wang, Liang Chen, Heng Wang, Dong Dong, Jingjing Zhu, Yu Guo, Yiqun Zhou, Tianyi Liu, Wei Fu
Format:	Article
Language:	English
Published:	Wiley 2025-01-01
Series:	Bioengineering & Translational Medicine
Subjects:	adipose‐derived multipotent stromal cells diabetic wound interleukin‐10 stem cell therapy therapeutic mRNA
Online Access:	https://doi.org/10.1002/btm2.10711
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Results of biochemical and histological studies after restoration of bone defects using cellular technologies in dental patients
by: А.V. Bambuliak, et al.
Published: (2024-06-01)

Use of multipotent mesenchymal stromal cells as part of bone marrow concentrate in the complex treatment of aseptic necrosis of the femoral head: a systematic review
by: Alina R. Zakirova, et al.
Published: (2024-12-01)

Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis
by: Damien Veret, et al.
Published: (2025-01-01)

Thymic Stromal-Cell Abnormalities and Dysregulated T-Cell Development in IL-2-Deficient Mice
by: Tannishtha Reya, et al.
Published: (1998-01-01)

Cell culture expansion media choice affects secretory, protective and immuno-modulatory features of adipose mesenchymal stromal cell-derived secretomes for orthopaedic applications
by: Enrico Ragni, et al.
Published: (2025-03-01)

Antimicrobial activity of adipose-derived mesenchymal stromal cell secretome against methicillin-resistant Staphylococcus aureus
by: Fatimah Shaaban, et al.
Published: (2025-01-01)

Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction
by: Fang Lyu, et al.
Published: (2025-01-01)

COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
by: Carla Longo de Freitas, et al.
Published: (2021-12-01)

COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
by: Carla Longo de Freitas, et al.
Published: (2021-12-01)

COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
by: Carla Longo de Freitas, et al.
Published: (2021-12-01)

Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment
by: Wu S, et al.
Published: (2025-02-01)

Exploring perinatal mesenchymal stromal cells as a potential therapeutic strategy for rheumatoid arthritis
by: Stefano Alivernini, et al.
Published: (2025-01-01)

Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis
by: Aliosha I. Figueroa-Valdés, et al.
Published: (2025-01-01)

Purification of mesenchymal stromal cell‐derived small extracellular vesicles using ultrafiltration
by: Rui Lei, et al.
Published: (2025-01-01)

Biosynthetic pathway for leukotrienes is stimulated by lipopolysaccharide and cytokines in pig endometrial stromal cells
by: Barbara Jana, et al.
Published: (2025-01-01)

Enucleated bone marrow-derived mesenchymal stromal cells regulate immune microenvironment and promote testosterone production through efferocytosis
by: Lu Sun, et al.
Published: (2025-02-01)

Rap1 Guanosine Triphosphate Hydrolase (GTPase) Regulates Shear Stress-Mediated Adhesion of Mesenchymal Stromal Cells
by: Melanie Giesen, et al.
Published: (2025-01-01)

Inhibitory effects of estetrol on the invasion and migration of immortalized human endometrial stromal cells
by: Akihiko Wakatsuki, et al.
Published: (2024-02-01)

The beneficial effects of thymoquinone on viability and differentiation of human adipose tissue-derived mesenchymal stem cells
by: Ahsen Erginsoy, et al.
Published: (2024-04-01)

Mesenchymal stromal cell exosomes for drug delivery of prostate cancer treatments: a review
by: Chengran Wang, et al.
Published: (2025-01-01)

Treatment with Autologous Adipose-derived Regenerative Cells for Peyronie’s Disease in Men: The Straight @head Pilot Study
by: Majken H. Wiborg, et al.
Published: (2025-01-01)

Gastrointestinal stromal tumors
by: A. P. Seryakov
Published: (2010-08-01)

Umbilical Cord Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Modulate Skin Matrix Synthesis and Pigmentation
by: Kee LT, et al.
Published: (2025-02-01)

Therapeutic potential of adipose-derived stem cells for diabetic foot ulcers: a systematic review and meta-analysis
by: Mohamed A. Abu Elainein, et al.
Published: (2025-01-01)

Exercise during pregnancy modulates infant cellular and whole‐body adiposity
by: Alex Claiborne, et al.
Published: (2024-12-01)

Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization
by: Peng-Chao Wang, et al.
Published: (2025-01-01)

cAMP analogues downregulate the expression of granulocyte macrophage colony-stimulating factor (GM-CSF) in human bone marrow stromal cells in vitro
by: G. Bug, et al.
Published: (1998-01-01)

Induced hepatocyte-like cells derived from adipose-derived stem cells alleviates liver injury in mice infected with Echinococcus Multilocularis
by: Hui Liu, et al.
Published: (2024-11-01)

Mesenchymal stromal cell-derived extracellular vesicles as nanotherapeutics for concanavalin a-induced hepatitis: modulating the gut‒liver axis
by: Fan Yang, et al.
Published: (2025-01-01)

Safety and efficacy of mesenchymal stromal cells mitochondria transplantation as a cell-free therapy for osteoarthritis
by: Ana Maria Vega-Letter, et al.
Published: (2025-01-01)

Exploring the interactions of rapamycin with target receptors in A549 cancer cells: insights from molecular docking analysis
by: Sanjeev K. Ganesh, et al.
Published: (2025-01-01)

Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury
by: Fei Yuan, et al.
Published: (2025-02-01)

Recent advances in adipose-derived mesenchymal stem cell-derived exosomes for regulating macrophage polarization
by: Zhewei Dong, et al.
Published: (2025-02-01)

Adipose-derived mesenchymal stem cells combined with platelet-rich plasma are superior options for the treatment of osteoarthritis
by: Weijie He, et al.
Published: (2025-01-01)

Mesenchymal stromal cells promote the formation of lung cancer organoids via Kindlin-2
by: Zhilin Sui, et al.
Published: (2025-01-01)

Functionality of endothelial cells differentiated from porcine epiblast stem cells, bone marrow-derived mesenchymal stem cells and adipose-derived mesenchymal stem cells
by: Yeon-Ji Lee, et al.
Published: (2024-12-01)

A case of stromal sarcoma of the prostate with the incidental detection of prostate adenocarcinoma
by: Shang Xu, et al.
Published: (2025-03-01)

Porcine pericardial decellularized matrix bilayer patch containing adipose stem cell-derived exosomes for the treatment of diabetic wounds
by: Wei Liang, et al.
Published: (2025-02-01)

Effect of cigarette smoke on the proliferation, viability, gene expression, and cellular functions of adipose-derived mesenchymal stem cells from smoking and non-smoking donors
by: Bareqa Salah, et al.
Published: (2024-12-01)

Differential regulation of apoptosis-related genes during long-term culture and differentiation of canine adipose-derived stem cells - a functional bioinformatical analysis
by: Maurycy Jankowski, et al.
Published: (2025-01-01)