Gaining insights into the physicochemical properties and sequence space of blood–brain barrier penetrating peptides

Gaining insights into the physicochemical properties and sequence space of blood–brain barrier penetrating peptides

The blood–brain barrier (BBB) poses a significant obstacle to the administration of drugs to the brain for the development of therapies of central nervous system (CNS) disorders. Blood-brain barrier penetrating peptides (BBBPps) are a group of peptides that can traverse the BBB by different processe...

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Bibliographic Details
Main Authors: Abhigyan Nath, Sneha Pandey, Kottakkaran Sooppy Nisar, Anoop Kumar Tiwari
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Egyptian Informatics Journal
Subjects:
Blood brain barrier penetrating peptides
Sequence properties
Physicochemical space
Gradient boosting machines
XGboost
Model agnostic interpretation methods
Online Access:http://www.sciencedirect.com/science/article/pii/S1110866524001208
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