Management of biological waste of patients after radionuclide therapy
Radioactive waste management is a modern-day issue in terms of radiation safety due to the development of radionuclide therapy, the emergence of new radiopharmaceuticals, radionuclides, and treatment methods, which allow for radionuclide therapy in a day hospital. According to the current domestic r...
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Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev
2022-06-01
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| Series: | Радиационная гигиена |
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| Online Access: | https://www.radhyg.ru/jour/article/view/869 |
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| author | L. A. Chipiga A. V. Vodovatov I. A. Zvonova A. A. Stanzhevsky A. V. Petryakova E. E. Anokina K. S. Velichkina S. A. Ryzhov |
| author_facet | L. A. Chipiga A. V. Vodovatov I. A. Zvonova A. A. Stanzhevsky A. V. Petryakova E. E. Anokina K. S. Velichkina S. A. Ryzhov |
| author_sort | L. A. Chipiga |
| collection | DOAJ |
| description | Radioactive waste management is a modern-day issue in terms of radiation safety due to the development of radionuclide therapy, the emergence of new radiopharmaceuticals, radionuclides, and treatment methods, which allow for radionuclide therapy in a day hospital. According to the current domestic regulatory and methodological support biological wastes generated during the patient’s metabolic activity after injection of the radiopharmaceuticals for the therapy refer to the liquid radioactive waste. These wastes must be collected and kept for decay in hospitals to the safe levels before being spilled into the municipal sewerage. It requires additional expenses to the hospital for making the special sewerage. To increase the availability of radionuclide therapy, it is necessary to update the requirements of the liquid radioactive waste management in nuclear medicine departments, considering the volume activities of different diagnostic and therapeutic radionuclides in wastes generated after the injection of radiopharmaceuticals to the patients. On the basis of findings, it is possible to evaluate the feasibility of the binding requirement for the availability of special sewerage in the departments of the radionuclide therapy. In this work, excretion of the radiopharmaceuticals used in therapy: 89Sr-dichloride, 223Ra-dichloride, 131I-MIBG, 177Lu-PSMA, and 225Ac-PSMA was studied based on published data to determine the activity levels of radionuclides in waste of patients. As a results of preliminary computations, some nuclear medicine procedure will not lead to generation of liquid radioactive waste from biological waste of patients in sewerage system in usual operating condition and special sewerage is not strictly necessary. For example, estimations of radionuclide activity in wastes showed the volume of current sewerage system in a small hospital with a limitation of 50 beds can be enough to reduce the level of specific activity of radionuclides in wastewater from one patient a day after radionuclide therapy with 89Sr-chloride and 223Ra-dichloride. In order to revision of requirements to special sewerage in each department of radionuclide therapy and to development of differentiated approach to the management of biological waste of patient in nuclear medicine departments, which ensure environment protection and radiation safety of people, it is necessary to continue the research including development and modeling of realistic scenario of staff and patient radiation exposure confirmed experimental results. |
| format | Article |
| id | doaj-art-bafb69d20b9c4953afb2a1a48b0e4de0 |
| institution | Kabale University |
| issn | 1998-426X |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev |
| record_format | Article |
| series | Радиационная гигиена |
| spelling | doaj-art-bafb69d20b9c4953afb2a1a48b0e4de02025-08-20T04:00:40ZengSaint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. RamzaevРадиационная гигиена1998-426X2022-06-01152193010.21514/1998-426X-2022-15-2-19-30745Management of biological waste of patients after radionuclide therapyL. A. Chipiga0A. V. Vodovatov1I. A. Zvonova2A. A. Stanzhevsky3A. V. Petryakova4E. E. Anokina5K. S. Velichkina6S. A. Ryzhov7Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing; A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation; Almazov National Medical Research Centre of the Ministry of Health of the Russian FederationSaint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing; Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-BeingA.M. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian FederationPeter the Great Saint-Petersburg Polytechnic University; Saint-Petersburg City Hospital No. 40Peter the Great Saint-Petersburg Polytechnic UniversityPeter the Great Saint-Petersburg Polytechnic UniversityAssociation of Medical Physicists in Russia; Research and Practice Center of Diagnostics and Telemedicine Technologies; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Health of the Russian FederationRadioactive waste management is a modern-day issue in terms of radiation safety due to the development of radionuclide therapy, the emergence of new radiopharmaceuticals, radionuclides, and treatment methods, which allow for radionuclide therapy in a day hospital. According to the current domestic regulatory and methodological support biological wastes generated during the patient’s metabolic activity after injection of the radiopharmaceuticals for the therapy refer to the liquid radioactive waste. These wastes must be collected and kept for decay in hospitals to the safe levels before being spilled into the municipal sewerage. It requires additional expenses to the hospital for making the special sewerage. To increase the availability of radionuclide therapy, it is necessary to update the requirements of the liquid radioactive waste management in nuclear medicine departments, considering the volume activities of different diagnostic and therapeutic radionuclides in wastes generated after the injection of radiopharmaceuticals to the patients. On the basis of findings, it is possible to evaluate the feasibility of the binding requirement for the availability of special sewerage in the departments of the radionuclide therapy. In this work, excretion of the radiopharmaceuticals used in therapy: 89Sr-dichloride, 223Ra-dichloride, 131I-MIBG, 177Lu-PSMA, and 225Ac-PSMA was studied based on published data to determine the activity levels of radionuclides in waste of patients. As a results of preliminary computations, some nuclear medicine procedure will not lead to generation of liquid radioactive waste from biological waste of patients in sewerage system in usual operating condition and special sewerage is not strictly necessary. For example, estimations of radionuclide activity in wastes showed the volume of current sewerage system in a small hospital with a limitation of 50 beds can be enough to reduce the level of specific activity of radionuclides in wastewater from one patient a day after radionuclide therapy with 89Sr-chloride and 223Ra-dichloride. In order to revision of requirements to special sewerage in each department of radionuclide therapy and to development of differentiated approach to the management of biological waste of patient in nuclear medicine departments, which ensure environment protection and radiation safety of people, it is necessary to continue the research including development and modeling of realistic scenario of staff and patient radiation exposure confirmed experimental results.https://www.radhyg.ru/jour/article/view/869nuclear medicineradionuclide therapybiological excretion of radiopharmaceuticalsliquid radioactive waste |
| spellingShingle | L. A. Chipiga A. V. Vodovatov I. A. Zvonova A. A. Stanzhevsky A. V. Petryakova E. E. Anokina K. S. Velichkina S. A. Ryzhov Management of biological waste of patients after radionuclide therapy Радиационная гигиена nuclear medicine radionuclide therapy biological excretion of radiopharmaceuticals liquid radioactive waste |
| title | Management of biological waste of patients after radionuclide therapy |
| title_full | Management of biological waste of patients after radionuclide therapy |
| title_fullStr | Management of biological waste of patients after radionuclide therapy |
| title_full_unstemmed | Management of biological waste of patients after radionuclide therapy |
| title_short | Management of biological waste of patients after radionuclide therapy |
| title_sort | management of biological waste of patients after radionuclide therapy |
| topic | nuclear medicine radionuclide therapy biological excretion of radiopharmaceuticals liquid radioactive waste |
| url | https://www.radhyg.ru/jour/article/view/869 |
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