Case Report of Atypical Juxtaglomerular Cell Tumor
Juxtaglomerular cell tumor (JGCT) is a rare renal tumor, producing renin and behaving almost in a benign fashion. So far, only three cases have been reported as malignant. We report a rare case with atypical JGCT. A 74-year-old male was referred to our hospital due to hypertension, proteinuria, and...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2018/6407360 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841524483349807104 |
|---|---|
| author | Satoru Munakata Eisuke Tomiyama Hitoshi Takayama |
| author_facet | Satoru Munakata Eisuke Tomiyama Hitoshi Takayama |
| author_sort | Satoru Munakata |
| collection | DOAJ |
| description | Juxtaglomerular cell tumor (JGCT) is a rare renal tumor, producing renin and behaving almost in a benign fashion. So far, only three cases have been reported as malignant. We report a rare case with atypical JGCT. A 74-year-old male was referred to our hospital due to hypertension, proteinuria, and hematuria. Abdominal CT revealed a mass measured in 9.7×7.0 cm in the lower portion of the right kidney. Right kidney was removed laparoscopically. Grossly, white to tan tumor with massive hemorrhage and necrosis occupied the lower portion of the right kidney. Microscopically, tumor grew in a solid fashion. Tumor cells were polygonal to ovoid cells with round nuclei and clear to eosinophilic cytoplasm. Mitosis was found in 5 per 10 HPF. Immunohistochemically, tumor cells were stained by vimentin and CD34. Some tumor cells were also positive for renin. Electron micrograph showed near rhomboid crystalline structure in the tumor cells. Because of massive necrosis and mitotic figures, diagnosis of atypical (potentially malignant) JGCT was rendered. Gene mutations for IDH1, PIK3CA, K-ras, N-ras, Braf, and EGFR were not found by MBP-QP system. |
| format | Article |
| id | doaj-art-baf28e1575404acdb24c0fff8f1a3e27 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-baf28e1575404acdb24c0fff8f1a3e272025-02-03T05:53:11ZengWileyCase Reports in Pathology2090-67812090-679X2018-01-01201810.1155/2018/64073606407360Case Report of Atypical Juxtaglomerular Cell TumorSatoru Munakata0Eisuke Tomiyama1Hitoshi Takayama2Departments of Pathology, Sakai City Hospital Organization, Sakai City Medical Center, Sakai, JapanDepartment of Urology, Sakai City Hospital Organization, Sakai City Medical Center, Sakai, JapanDepartment of Urology, Sakai City Hospital Organization, Sakai City Medical Center, Sakai, JapanJuxtaglomerular cell tumor (JGCT) is a rare renal tumor, producing renin and behaving almost in a benign fashion. So far, only three cases have been reported as malignant. We report a rare case with atypical JGCT. A 74-year-old male was referred to our hospital due to hypertension, proteinuria, and hematuria. Abdominal CT revealed a mass measured in 9.7×7.0 cm in the lower portion of the right kidney. Right kidney was removed laparoscopically. Grossly, white to tan tumor with massive hemorrhage and necrosis occupied the lower portion of the right kidney. Microscopically, tumor grew in a solid fashion. Tumor cells were polygonal to ovoid cells with round nuclei and clear to eosinophilic cytoplasm. Mitosis was found in 5 per 10 HPF. Immunohistochemically, tumor cells were stained by vimentin and CD34. Some tumor cells were also positive for renin. Electron micrograph showed near rhomboid crystalline structure in the tumor cells. Because of massive necrosis and mitotic figures, diagnosis of atypical (potentially malignant) JGCT was rendered. Gene mutations for IDH1, PIK3CA, K-ras, N-ras, Braf, and EGFR were not found by MBP-QP system.http://dx.doi.org/10.1155/2018/6407360 |
| spellingShingle | Satoru Munakata Eisuke Tomiyama Hitoshi Takayama Case Report of Atypical Juxtaglomerular Cell Tumor Case Reports in Pathology |
| title | Case Report of Atypical Juxtaglomerular Cell Tumor |
| title_full | Case Report of Atypical Juxtaglomerular Cell Tumor |
| title_fullStr | Case Report of Atypical Juxtaglomerular Cell Tumor |
| title_full_unstemmed | Case Report of Atypical Juxtaglomerular Cell Tumor |
| title_short | Case Report of Atypical Juxtaglomerular Cell Tumor |
| title_sort | case report of atypical juxtaglomerular cell tumor |
| url | http://dx.doi.org/10.1155/2018/6407360 |
| work_keys_str_mv | AT satorumunakata casereportofatypicaljuxtaglomerularcelltumor AT eisuketomiyama casereportofatypicaljuxtaglomerularcelltumor AT hitoshitakayama casereportofatypicaljuxtaglomerularcelltumor |