Intravenous meropenem and intraperitoneal use of 10% aqueous extract of Schinus terebinthifolius Raddi (Anacardiaceae) in elderly rats after induction of autogenous fecal peritonitis
ABSTRACT Purpose: To evaluate intravenous meropenem and intraperitoneal 10% aqueous extract of Schinus terebinthifolius (aroeira) in elderly rats after autogenous fecal peritonitis. Methods: Thirty 18-month-old Wistar rats underwent peritonitis with 4 mL/kg of autogenous fecal solution. They were...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2025-01-01
|
| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100202&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841538692673437696 |
|---|---|
| author | Carlos Alberto Figueiredo Filho Celia Maria Machado Barbosa de Castro Guilherme Veras Mascena Gustavo Ithamar Souto Maior Tharcia Kiara Beserra Oliveira Carlos Teixeira Brandt |
| author_facet | Carlos Alberto Figueiredo Filho Celia Maria Machado Barbosa de Castro Guilherme Veras Mascena Gustavo Ithamar Souto Maior Tharcia Kiara Beserra Oliveira Carlos Teixeira Brandt |
| author_sort | Carlos Alberto Figueiredo Filho |
| collection | DOAJ |
| description | ABSTRACT Purpose: To evaluate intravenous meropenem and intraperitoneal 10% aqueous extract of Schinus terebinthifolius (aroeira) in elderly rats after autogenous fecal peritonitis. Methods: Thirty 18-month-old Wistar rats underwent peritonitis with 4 mL/kg of autogenous fecal solution. They were stratified into groups: control without treatment; study I, treated with meropenem (40 mg/kg); and study II, treated with meropenem at the same dose and intraperitoneal 10% aqueous extract of aroeira. The animals were monitored for 15 days until euthanasia. The study was approved by Ethics Committee. Results: There was no significant weight loss in the study-II group (p = 0.6277), while the study-I group showed partially recovered weight (p = 0.0187). The study-II group had 90% negative blood cultures, while the study-I group had in 50% of the animals (p = 0.1479). Survival in the study-II group was higher than in study-I group (p = 0.0462). The morbidity score for abdominal and thoracic cavity was lower in the study-II group as compared with study-I group (p = 0.0001). Conclusions: The use of meropenem associated with the intraperitoneal 10% aqueous aroeira extract after induction of autogenous fecal peritonitis in elderly rats produced greater survival, less weight loss, and lower morbidity compared to the use of meropenem alone. |
| format | Article |
| id | doaj-art-bad8691be094499782afb3285542f7b9 |
| institution | Kabale University |
| issn | 1678-2674 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj-art-bad8691be094499782afb3285542f7b92025-01-14T07:40:06ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira1678-26742025-01-014010.1590/acb400325Intravenous meropenem and intraperitoneal use of 10% aqueous extract of Schinus terebinthifolius Raddi (Anacardiaceae) in elderly rats after induction of autogenous fecal peritonitisCarlos Alberto Figueiredo Filhohttps://orcid.org/0000-0001-7650-721XCelia Maria Machado Barbosa de Castrohttps://orcid.org/0000-0003-4910-3476Guilherme Veras Mascenahttps://orcid.org/0009-0008-4879-8492Gustavo Ithamar Souto Maiorhttps://orcid.org/0009-0007-6176-5671Tharcia Kiara Beserra Oliveirahttps://orcid.org/0000-0001-6352-7254Carlos Teixeira Brandthttps://orcid.org/0000-0002-9614-816XABSTRACT Purpose: To evaluate intravenous meropenem and intraperitoneal 10% aqueous extract of Schinus terebinthifolius (aroeira) in elderly rats after autogenous fecal peritonitis. Methods: Thirty 18-month-old Wistar rats underwent peritonitis with 4 mL/kg of autogenous fecal solution. They were stratified into groups: control without treatment; study I, treated with meropenem (40 mg/kg); and study II, treated with meropenem at the same dose and intraperitoneal 10% aqueous extract of aroeira. The animals were monitored for 15 days until euthanasia. The study was approved by Ethics Committee. Results: There was no significant weight loss in the study-II group (p = 0.6277), while the study-I group showed partially recovered weight (p = 0.0187). The study-II group had 90% negative blood cultures, while the study-I group had in 50% of the animals (p = 0.1479). Survival in the study-II group was higher than in study-I group (p = 0.0462). The morbidity score for abdominal and thoracic cavity was lower in the study-II group as compared with study-I group (p = 0.0001). Conclusions: The use of meropenem associated with the intraperitoneal 10% aqueous aroeira extract after induction of autogenous fecal peritonitis in elderly rats produced greater survival, less weight loss, and lower morbidity compared to the use of meropenem alone.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100202&lng=en&tlng=enPeritonitisAgedCarbapenemsRatsAnacardiaceae |
| spellingShingle | Carlos Alberto Figueiredo Filho Celia Maria Machado Barbosa de Castro Guilherme Veras Mascena Gustavo Ithamar Souto Maior Tharcia Kiara Beserra Oliveira Carlos Teixeira Brandt Intravenous meropenem and intraperitoneal use of 10% aqueous extract of Schinus terebinthifolius Raddi (Anacardiaceae) in elderly rats after induction of autogenous fecal peritonitis Acta Cirúrgica Brasileira Peritonitis Aged Carbapenems Rats Anacardiaceae |
| title | Intravenous meropenem and intraperitoneal use of 10% aqueous extract of Schinus terebinthifolius Raddi (Anacardiaceae) in elderly rats after induction of autogenous fecal peritonitis |
| title_full | Intravenous meropenem and intraperitoneal use of 10% aqueous extract of Schinus terebinthifolius Raddi (Anacardiaceae) in elderly rats after induction of autogenous fecal peritonitis |
| title_fullStr | Intravenous meropenem and intraperitoneal use of 10% aqueous extract of Schinus terebinthifolius Raddi (Anacardiaceae) in elderly rats after induction of autogenous fecal peritonitis |
| title_full_unstemmed | Intravenous meropenem and intraperitoneal use of 10% aqueous extract of Schinus terebinthifolius Raddi (Anacardiaceae) in elderly rats after induction of autogenous fecal peritonitis |
| title_short | Intravenous meropenem and intraperitoneal use of 10% aqueous extract of Schinus terebinthifolius Raddi (Anacardiaceae) in elderly rats after induction of autogenous fecal peritonitis |
| title_sort | intravenous meropenem and intraperitoneal use of 10 aqueous extract of schinus terebinthifolius raddi anacardiaceae in elderly rats after induction of autogenous fecal peritonitis |
| topic | Peritonitis Aged Carbapenems Rats Anacardiaceae |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100202&lng=en&tlng=en |
| work_keys_str_mv | AT carlosalbertofigueiredofilho intravenousmeropenemandintraperitonealuseof10aqueousextractofschinusterebinthifoliusraddianacardiaceaeinelderlyratsafterinductionofautogenousfecalperitonitis AT celiamariamachadobarbosadecastro intravenousmeropenemandintraperitonealuseof10aqueousextractofschinusterebinthifoliusraddianacardiaceaeinelderlyratsafterinductionofautogenousfecalperitonitis AT guilhermeverasmascena intravenousmeropenemandintraperitonealuseof10aqueousextractofschinusterebinthifoliusraddianacardiaceaeinelderlyratsafterinductionofautogenousfecalperitonitis AT gustavoithamarsoutomaior intravenousmeropenemandintraperitonealuseof10aqueousextractofschinusterebinthifoliusraddianacardiaceaeinelderlyratsafterinductionofautogenousfecalperitonitis AT tharciakiarabeserraoliveira intravenousmeropenemandintraperitonealuseof10aqueousextractofschinusterebinthifoliusraddianacardiaceaeinelderlyratsafterinductionofautogenousfecalperitonitis AT carlosteixeirabrandt intravenousmeropenemandintraperitonealuseof10aqueousextractofschinusterebinthifoliusraddianacardiaceaeinelderlyratsafterinductionofautogenousfecalperitonitis |