Omeprazole with Calcium Hydroxide’s Effectiveness as an Intracanal Medication against Enterococcus faecalis
Aims: To evaluate the effectiveness of omeprazole mixed with calcium hydroxide (Ca(OH)2), as intracanal medicament in eliminating Enterococcus faecalis. Materials and Methods: Our study included 93 extracted mandibular premolars. A total of 15 μL of 0.5 McFarland standard E. faecalis (ATCC 29212) wa...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1185_24 |
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| Summary: | Aims:
To evaluate the effectiveness of omeprazole mixed with calcium hydroxide (Ca(OH)2), as intracanal medicament in eliminating Enterococcus faecalis.
Materials and Methods:
Our study included 93 extracted mandibular premolars. A total of 15 μL of 0.5 McFarland standard E. faecalis (ATCC 29212) was inoculated into each canal and incubated at 36.5°C for 24 h. The specimens were divided into three groups: Group I (n = 30), control group without intracanal medicament, Group II (n = 30) with Ca(OH)2 and Group III (n = 30) with omeprazole and Ca(OH)2. The numbers of colony forming units (CFUs) were counted after 24 h. The same procedure was repeated after 7 and 14 days for the remaining samples.
Statistical Analysis Use:
Statistical analysis was performed using the analysis of variance (ANOVA) test (P < 0.05).
Results:
We found a significant reduction in the colony-forming unit count in the omeprazole– Ca(OH)2 group. In the Ca(OH)2 group, the number of CFUs was significantly higher than in the omeprazole–Ca(OH)2 group.
Conclusion:
Omeprazole mixed with Ca(OH)2 was more effective than Ca(OH)2 alone in eliminating E. faecalis. |
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| ISSN: | 0976-4879 0975-7406 |