Increased serum galectin-3 level is associated with endothelial dysfunction and cardiovascular events in patients with hypertension
Background: Endothelial dysfunction can lead to various harmful cardiovascular complications. The importance of galectin-3 (Gal-3) has been proposed in some cardiac diseases related to chronic inflammation. However, its role in hypertension-induced endothelial dysfunction remains unclear. Methods: W...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024171423 |
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| author | Hui-Sheng Wang Bang-Gee Hsu Ji-Hung Wang Chiu-Fen Yang |
| author_facet | Hui-Sheng Wang Bang-Gee Hsu Ji-Hung Wang Chiu-Fen Yang |
| author_sort | Hui-Sheng Wang |
| collection | DOAJ |
| description | Background: Endothelial dysfunction can lead to various harmful cardiovascular complications. The importance of galectin-3 (Gal-3) has been proposed in some cardiac diseases related to chronic inflammation. However, its role in hypertension-induced endothelial dysfunction remains unclear. Methods: We enrolled 120 patients with hypertension, assessed their baseline characteristics, and monitored their 7-year cardiovascular outcomes. We performed an enzyme-linked immunosorbent assay to measure serum Gal-3 levels. The vascular reactivity index (VRI) was examined by digital thermal monitoring. Patients with VRI <1.0, 1.0 to <2.0, and ≥2.0 were defined as having poor, intermediate, and good vascular reactivity, respectively. Results: Among the recruited patients, 12 had poor vascular reactivity, 57 had intermediate vascular reactivity, and 51 had good vascular reactivity. Older age, higher total cholesterol levels, higher low-density lipoprotein cholesterol levels, lower estimated glomerular filtration rate, and higher Gal-3 levels were associated with poor endothelial dysfunction. Multivariate linear regression analysis showed that age and Gal-3 levels were correlated with VRI. During the 7-year follow-up period, patients with higher Gal-3 levels had more cardiovascular events. Conclusions: Higher Gal-3 levels are associated with endothelial dysfunction and unfavorable cardiovascular outcomes in patients with hypertension, suggesting its potential role in the hypertension-induced endothelial dysfunction. |
| format | Article |
| id | doaj-art-ba636bf77f534a0ab26e926a74c339b9 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-ba636bf77f534a0ab26e926a74c339b92025-01-17T04:50:11ZengElsevierHeliyon2405-84402025-01-01111e41111Increased serum galectin-3 level is associated with endothelial dysfunction and cardiovascular events in patients with hypertensionHui-Sheng Wang0Bang-Gee Hsu1Ji-Hung Wang2Chiu-Fen Yang3Division of Cardiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, TaiwanDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, TaiwanDivision of Cardiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan; Cardiovascular Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, TaiwanDivision of Cardiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan; Cardiovascular Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Corresponding author. Division of Cardiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 707, Section 3, Chung Yang Road, Hualien, Taiwan.Background: Endothelial dysfunction can lead to various harmful cardiovascular complications. The importance of galectin-3 (Gal-3) has been proposed in some cardiac diseases related to chronic inflammation. However, its role in hypertension-induced endothelial dysfunction remains unclear. Methods: We enrolled 120 patients with hypertension, assessed their baseline characteristics, and monitored their 7-year cardiovascular outcomes. We performed an enzyme-linked immunosorbent assay to measure serum Gal-3 levels. The vascular reactivity index (VRI) was examined by digital thermal monitoring. Patients with VRI <1.0, 1.0 to <2.0, and ≥2.0 were defined as having poor, intermediate, and good vascular reactivity, respectively. Results: Among the recruited patients, 12 had poor vascular reactivity, 57 had intermediate vascular reactivity, and 51 had good vascular reactivity. Older age, higher total cholesterol levels, higher low-density lipoprotein cholesterol levels, lower estimated glomerular filtration rate, and higher Gal-3 levels were associated with poor endothelial dysfunction. Multivariate linear regression analysis showed that age and Gal-3 levels were correlated with VRI. During the 7-year follow-up period, patients with higher Gal-3 levels had more cardiovascular events. Conclusions: Higher Gal-3 levels are associated with endothelial dysfunction and unfavorable cardiovascular outcomes in patients with hypertension, suggesting its potential role in the hypertension-induced endothelial dysfunction.http://www.sciencedirect.com/science/article/pii/S2405844024171423Galectin-3HypertensionVascular reactivity indexEndothelial dysfunctionCardiovascular events |
| spellingShingle | Hui-Sheng Wang Bang-Gee Hsu Ji-Hung Wang Chiu-Fen Yang Increased serum galectin-3 level is associated with endothelial dysfunction and cardiovascular events in patients with hypertension Heliyon Galectin-3 Hypertension Vascular reactivity index Endothelial dysfunction Cardiovascular events |
| title | Increased serum galectin-3 level is associated with endothelial dysfunction and cardiovascular events in patients with hypertension |
| title_full | Increased serum galectin-3 level is associated with endothelial dysfunction and cardiovascular events in patients with hypertension |
| title_fullStr | Increased serum galectin-3 level is associated with endothelial dysfunction and cardiovascular events in patients with hypertension |
| title_full_unstemmed | Increased serum galectin-3 level is associated with endothelial dysfunction and cardiovascular events in patients with hypertension |
| title_short | Increased serum galectin-3 level is associated with endothelial dysfunction and cardiovascular events in patients with hypertension |
| title_sort | increased serum galectin 3 level is associated with endothelial dysfunction and cardiovascular events in patients with hypertension |
| topic | Galectin-3 Hypertension Vascular reactivity index Endothelial dysfunction Cardiovascular events |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024171423 |
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