STAT1/STAT3 Gain of Function and Mechanisms of Immune Dysregulation
The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling pathways are essential for maintaining prompt immune responses to various cytokines. Both loss- and gain-of-function mutations in the JAK and STAT molecules result in different disease profiles in inborn err...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-04-01
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| Series: | Turkish Journal of Immunology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-52386 |
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| _version_ | 1841525406383996928 |
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| author | Ayça Kıykım |
| author_facet | Ayça Kıykım |
| author_sort | Ayça Kıykım |
| collection | DOAJ |
| description | The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling pathways are essential for maintaining prompt immune responses to various cytokines. Both loss- and gain-of-function mutations in the JAK and STAT molecules result in different disease profiles in inborn errors of immunity. The discovery of gain-of-function mutations in STAT1 and STAT3 expanded immunological investigations aimed at understanding both signaling pathways and their associated disorders. Both defects are distinct from loss-of-function mutations that lead to alterations in immune regulation. In this context, we wanted to take a look at both diseases and focus on the mechanisms. |
| format | Article |
| id | doaj-art-ba4f1c649e0f4faea731f83b2e7b85ae |
| institution | Kabale University |
| issn | 1301-109X 2147-8325 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Immunology |
| spelling | doaj-art-ba4f1c649e0f4faea731f83b2e7b85ae2025-01-17T13:55:52ZengGalenos Publishing HouseTurkish Journal of Immunology1301-109X2147-83252024-04-0112Suppl 1475210.4274/tji.galenos.2023.52386TJI-52386STAT1/STAT3 Gain of Function and Mechanisms of Immune DysregulationAyça Kıykım0İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Pediatrics, Division of Pediatric Allergy and Immunology, İstanbul, TurkeyThe Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling pathways are essential for maintaining prompt immune responses to various cytokines. Both loss- and gain-of-function mutations in the JAK and STAT molecules result in different disease profiles in inborn errors of immunity. The discovery of gain-of-function mutations in STAT1 and STAT3 expanded immunological investigations aimed at understanding both signaling pathways and their associated disorders. Both defects are distinct from loss-of-function mutations that lead to alterations in immune regulation. In this context, we wanted to take a look at both diseases and focus on the mechanisms.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-52386janus tyrosine kinasesignal transducer and activator of transcriptiongain of functionimmune dysregulationautoimmunity |
| spellingShingle | Ayça Kıykım STAT1/STAT3 Gain of Function and Mechanisms of Immune Dysregulation Turkish Journal of Immunology janus tyrosine kinase signal transducer and activator of transcription gain of function immune dysregulation autoimmunity |
| title | STAT1/STAT3 Gain of Function and Mechanisms of Immune Dysregulation |
| title_full | STAT1/STAT3 Gain of Function and Mechanisms of Immune Dysregulation |
| title_fullStr | STAT1/STAT3 Gain of Function and Mechanisms of Immune Dysregulation |
| title_full_unstemmed | STAT1/STAT3 Gain of Function and Mechanisms of Immune Dysregulation |
| title_short | STAT1/STAT3 Gain of Function and Mechanisms of Immune Dysregulation |
| title_sort | stat1 stat3 gain of function and mechanisms of immune dysregulation |
| topic | janus tyrosine kinase signal transducer and activator of transcription gain of function immune dysregulation autoimmunity |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tji&un=TJI-52386 |
| work_keys_str_mv | AT aycakıykım stat1stat3gainoffunctionandmechanismsofimmunedysregulation |