The role of autophagy related signal transduction pathways in bone metabolism
Autophagy is an effective protective mechanism against tissue degeneration and plays an important role in cell proliferation, differentiation and maturation. The main cells involved in bone me-tabolism include osteoblasts and osteoclasts, which play an important role in bone development and maintena...
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| Format: | Article |
| Language: | zho |
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Editorial Office of New Medicine
2022-02-01
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| Series: | Yixue xinzhi zazhi |
| Subjects: | |
| Online Access: | https://yxxz.whuznhmedj.com/storage/attach/2202/XcctVnVjzgDE6cQPTK9HqocvFjJaqJKoJvEfnvL4.pdf |
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| _version_ | 1846108093468901376 |
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| author | Zhi-Zhuo LI Li-Jun SHI Fu-Qiang GAO Wei SUN |
| author_facet | Zhi-Zhuo LI Li-Jun SHI Fu-Qiang GAO Wei SUN |
| author_sort | Zhi-Zhuo LI |
| collection | DOAJ |
| description | Autophagy is an effective protective mechanism against tissue degeneration and plays an important role in cell proliferation, differentiation and maturation. The main cells involved in bone me-tabolism include osteoblasts and osteoclasts, which play an important role in bone development and maintenance. It has been found that the level of autophagy is regulated by sirtuin1 (SIRT1) and mito-gen-activated protein kinase 8 (MAPK8)/forkhead box O3 (FOXO3) in osteoblasts. In osteoclasts, the level of autophagy is regulated mainly by Bcl-2 interacting coiled-coil protein 1 (Beclin-1), p62/sequestosome 1 (p62/SQSTM1), mammalian target of rapamycin (mTOR) and hypoxia-inducible factor-1α (HIF-1α). The main focus of this article is a discussion of the autophagy related signal trans-duction pathways in bone metabolism and an analysis of the regulation of autophagy in osteoblasts and osteoclasts. |
| format | Article |
| id | doaj-art-ba47b241509b417ca74a611c909e4467 |
| institution | Kabale University |
| issn | 1004-5511 |
| language | zho |
| publishDate | 2022-02-01 |
| publisher | Editorial Office of New Medicine |
| record_format | Article |
| series | Yixue xinzhi zazhi |
| spelling | doaj-art-ba47b241509b417ca74a611c909e44672024-12-26T03:01:39ZzhoEditorial Office of New MedicineYixue xinzhi zazhi1004-55112022-02-01321646810.12173/j.issn.1004-5511.2020110326255The role of autophagy related signal transduction pathways in bone metabolismZhi-Zhuo LILi-Jun SHIFu-Qiang GAOWei SUNAutophagy is an effective protective mechanism against tissue degeneration and plays an important role in cell proliferation, differentiation and maturation. The main cells involved in bone me-tabolism include osteoblasts and osteoclasts, which play an important role in bone development and maintenance. It has been found that the level of autophagy is regulated by sirtuin1 (SIRT1) and mito-gen-activated protein kinase 8 (MAPK8)/forkhead box O3 (FOXO3) in osteoblasts. In osteoclasts, the level of autophagy is regulated mainly by Bcl-2 interacting coiled-coil protein 1 (Beclin-1), p62/sequestosome 1 (p62/SQSTM1), mammalian target of rapamycin (mTOR) and hypoxia-inducible factor-1α (HIF-1α). The main focus of this article is a discussion of the autophagy related signal trans-duction pathways in bone metabolism and an analysis of the regulation of autophagy in osteoblasts and osteoclasts.https://yxxz.whuznhmedj.com/storage/attach/2202/XcctVnVjzgDE6cQPTK9HqocvFjJaqJKoJvEfnvL4.pdfautophagy signal transduction pathway bone metabolism osteoblast osteoclast |
| spellingShingle | Zhi-Zhuo LI Li-Jun SHI Fu-Qiang GAO Wei SUN The role of autophagy related signal transduction pathways in bone metabolism Yixue xinzhi zazhi autophagy signal transduction pathway bone metabolism osteoblast osteoclast |
| title | The role of autophagy related signal transduction pathways in bone metabolism |
| title_full | The role of autophagy related signal transduction pathways in bone metabolism |
| title_fullStr | The role of autophagy related signal transduction pathways in bone metabolism |
| title_full_unstemmed | The role of autophagy related signal transduction pathways in bone metabolism |
| title_short | The role of autophagy related signal transduction pathways in bone metabolism |
| title_sort | role of autophagy related signal transduction pathways in bone metabolism |
| topic | autophagy signal transduction pathway bone metabolism osteoblast osteoclast |
| url | https://yxxz.whuznhmedj.com/storage/attach/2202/XcctVnVjzgDE6cQPTK9HqocvFjJaqJKoJvEfnvL4.pdf |
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