Insight into blood proteinase-inhibitor system and pathogenesis of renal tuberculosis induced by phylogenomically different Mycobacterium tuberculosis strains in rabbit model

Insight into blood proteinase-inhibitor system and pathogenesis of renal tuberculosis induced by phylogenomically different Mycobacterium tuberculosis strains in rabbit model

Abstract Background This study aimed to evaluate the impact of different Mycobacterium tuberculosis strains on the blood proteinase-inhibitor system and structural changes in the renal parenchyma during the pathogenesis of renal tuberculosis in a rabbit model. Methods Renal tuberculosis was modeled...

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Main Authors: Dilyara Esmedlyaeva, Igor Mokrousov, Nina Alekseeva, Natalia Blum, Marina Dyakova, Marine Dogonadze, Anna Vyazovaya, Dmitrii Polev, Boris Ariel, Tatiana Vinogradova, Petr Yablonsky
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Nephrology
Subjects:
Mycobacterium tuberculosis
Extracellular matrix
Matrix metalloproteinases
Proteinase inhibitors
Cystatin c
Renal tuberculosis
Online Access:https://doi.org/10.1186/s12882-025-04411-w
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