Optimization of SARS-CoV-2 culture from clinical samples for clinical trial applications

Optimization of SARS-CoV-2 culture from clinical samples for clinical trial applications

ABSTRACT Clinical trials of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) therapeutics often include virological secondary endpoints to compare viral clearance and viral load reduction between treatment and placebo arms. This is typically achieved using quantitative reverse-transcript...

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Main Authors: Dominic Wooding, Kate Buist, Alessandra Romero-Ramirez, Helen Savage, Rachel Watkins, Daisy Bengey, Caitlin Greenland-Bews, Caitlin R. Thompson, Nadia Kontogianni, Richard Body, Gail Hayward, Rachel L. Byrne, Susan Gould, Christopher Myerscough, Barry Atkinson, Victoria Shaw, Bill Greenhalf, Emily Adams, Ana Cubas-Atienzar, Saye Khoo, Tom Fletcher, Thomas Edwards
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mSphere
Subjects:
molecular diagnostics
clinical trials
COVID-19
Online Access:https://journals.asm.org/doi/10.1128/msphere.00304-24
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