Assessment of Feasibility of the M2 Macrophage-Based Adoptive Gene Transfer Strategy for Osteoarthritis with a Mouse Model

Assessment of Feasibility of the M2 Macrophage-Based Adoptive Gene Transfer Strategy for Osteoarthritis with a Mouse Model

Current osteoarthritis (OA) therapies fail to yield long-term clinical benefits, due in part to the lack of a mechanism for the targeted and confined delivery of therapeutics to OA joints. This study evaluates if M2 macrophages are effective cell vehicles for the targeted and confined delivery of th...

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Bibliographic Details
Main Authors: Matilda H.-C. Sheng, David J. Baylink, Charles H. Rundle, Kin-Hing William Lau
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
macrophages
inflammation
IL-1Ra
osteoarthritis
adoptive gene transfer
treatment
Online Access:https://www.mdpi.com/2073-4409/14/14/1067
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