Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells

Unveiling the Role of TMPRSS2 in the Proteolytic Activation of Pandemic and Zoonotic Influenza Viruses and Coronaviruses in Human Airway Cells

The zoonotic transmission of influenza A viruses (IAVs) and coronaviruses (CoVs) may result in severe disease. Cleavage of the surface glycoproteins hemagglutinin (HA) and spike protein (S), respectively, is essential for viral infectivity. The transmembrane serine protease 2 (TMPRSS2) is crucial fo...

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Bibliographic Details
Main Authors: Marie Schwerdtner, Luna C. Schmacke, Julia Nave, Hannah Limburg, Torsten Steinmetzer, David A. Stein, Hong M. Moulton, Eva Böttcher-Friebertshäuser
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Viruses
Subjects:
influenza A virus
coronavirus
TMPRSS2
proteolytic activation
SARS-CoV
MERS-CoV
Online Access:https://www.mdpi.com/1999-4915/16/11/1798
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