Medication adherence among Jordanian adults with chronic conditions: a combined analysis using regression and machine learning
Background Managing chronic illness effectively depends not only on treatment availability but also on patients’ ability to adhere to prescribed medications.Objectives This study examined the factors influencing medication adherence among Jordanian adults with long-term conditions, using both tradit...
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| Format: | Article |
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2548979 |
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| author | Walid Al-Qerem Anan Jarab Judith Eberhardt Salwa Abdo Lujain Al-sa’di Razan Al-Shehadeh Dana Khasim Ruba Zumot Sarah Khalil |
| author_facet | Walid Al-Qerem Anan Jarab Judith Eberhardt Salwa Abdo Lujain Al-sa’di Razan Al-Shehadeh Dana Khasim Ruba Zumot Sarah Khalil |
| author_sort | Walid Al-Qerem |
| collection | DOAJ |
| description | Background Managing chronic illness effectively depends not only on treatment availability but also on patients’ ability to adhere to prescribed medications.Objectives This study examined the factors influencing medication adherence among Jordanian adults with long-term conditions, using both traditional regression and machine learning methods.Method In this cross-sectional study, patients with chronic conditions completed an online survey that assessed demographic, clinical and behavioural variables, including Health Literacy Questionnaire (HLQ-12) and adherence (MARS-5). Quantile regression and machine learning models were applied.Results A total of 981 patients (63.1% females) were enrolled in the study. Quantile regression showed that higher health literacy, a diagnosis of diabetes or cardiovascular disease, and fewer prescribed medications were positively associated with adherence. In contrast, being married or having public, military or no insurance was linked to lower adherence scores. The Random Forest model achieved the highest predictive accuracy (R2 = 0.38), and SHAP analysis identified health literacy, disease duration and age as the most influential features.Conclusions These findings highlight the need for targeted interventions that address both individual understanding and structural challenges, such as insurance type and treatment complexity. Improving health literacy, simplifying medication regimens, and ensuring equitable healthcare access may help support better adherence in this population. The use of explainable machine learning, alongside conventional statistical approaches, offers new opportunities to improve the understanding and prediction of adherence behaviours in resource-constrained settings. |
| format | Article |
| id | doaj-art-b9d5d68f590d4543a1a24f6913e1de67 |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-b9d5d68f590d4543a1a24f6913e1de672025-08-20T16:02:43ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2548979Medication adherence among Jordanian adults with chronic conditions: a combined analysis using regression and machine learningWalid Al-Qerem0Anan Jarab1Judith Eberhardt2Salwa Abdo3Lujain Al-sa’di4Razan Al-Shehadeh5Dana Khasim6Ruba Zumot7Sarah Khalil8Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, JordanDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, JordanDepartment of Psychology, School of Social Sciences, Humanities and Law, Teesside University, Middlesbrough, UKDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, JordanDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, JordanDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, JordanDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, JordanDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, JordanDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, JordanBackground Managing chronic illness effectively depends not only on treatment availability but also on patients’ ability to adhere to prescribed medications.Objectives This study examined the factors influencing medication adherence among Jordanian adults with long-term conditions, using both traditional regression and machine learning methods.Method In this cross-sectional study, patients with chronic conditions completed an online survey that assessed demographic, clinical and behavioural variables, including Health Literacy Questionnaire (HLQ-12) and adherence (MARS-5). Quantile regression and machine learning models were applied.Results A total of 981 patients (63.1% females) were enrolled in the study. Quantile regression showed that higher health literacy, a diagnosis of diabetes or cardiovascular disease, and fewer prescribed medications were positively associated with adherence. In contrast, being married or having public, military or no insurance was linked to lower adherence scores. The Random Forest model achieved the highest predictive accuracy (R2 = 0.38), and SHAP analysis identified health literacy, disease duration and age as the most influential features.Conclusions These findings highlight the need for targeted interventions that address both individual understanding and structural challenges, such as insurance type and treatment complexity. Improving health literacy, simplifying medication regimens, and ensuring equitable healthcare access may help support better adherence in this population. The use of explainable machine learning, alongside conventional statistical approaches, offers new opportunities to improve the understanding and prediction of adherence behaviours in resource-constrained settings.https://www.tandfonline.com/doi/10.1080/07853890.2025.2548979Medication adherenceJordanhealth literacychronic diseasescardiovascular diseasesrandom Forest |
| spellingShingle | Walid Al-Qerem Anan Jarab Judith Eberhardt Salwa Abdo Lujain Al-sa’di Razan Al-Shehadeh Dana Khasim Ruba Zumot Sarah Khalil Medication adherence among Jordanian adults with chronic conditions: a combined analysis using regression and machine learning Annals of Medicine Medication adherence Jordan health literacy chronic diseases cardiovascular diseases random Forest |
| title | Medication adherence among Jordanian adults with chronic conditions: a combined analysis using regression and machine learning |
| title_full | Medication adherence among Jordanian adults with chronic conditions: a combined analysis using regression and machine learning |
| title_fullStr | Medication adherence among Jordanian adults with chronic conditions: a combined analysis using regression and machine learning |
| title_full_unstemmed | Medication adherence among Jordanian adults with chronic conditions: a combined analysis using regression and machine learning |
| title_short | Medication adherence among Jordanian adults with chronic conditions: a combined analysis using regression and machine learning |
| title_sort | medication adherence among jordanian adults with chronic conditions a combined analysis using regression and machine learning |
| topic | Medication adherence Jordan health literacy chronic diseases cardiovascular diseases random Forest |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2548979 |
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