VASN knockout induces myocardial fibrosis in mice by downregulating non-collagen fibers and promoting inflammation

VASN knockout induces myocardial fibrosis in mice by downregulating non-collagen fibers and promoting inflammation

Myocardial fibrosis (MF) is an important cause of heart failure and cardiac arrest. Vasorin knockout (VASN−/−) leads to pathological cardiac hypertrophy (PCH); however, it is not yet clear whether this PCH transitions to MF in mice. VASN-knockout mice showed typical pathological, imaging, and molecu...

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Bibliographic Details
Main Authors: Junming Sun, Siwei Yin, Qiurui Li, Jun Zhang, Xiaoping Guo, Na Yu, Bing Hu, Yiqiang Ouyang, Qiaojuan Huang, Min He
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
myocardial fibrosis
vasorin
non-collagen fibers
inflammation
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1500617/full
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