Functional and mechanistic advantage of the use of a bifunctional anti-PD-L1/IL-15 superagonist

Background Anti(α)-programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) monotherapy fails to provide durable clinical benefit for most patients with carcinoma. Recent studies suggested that strategies to reduce immunosuppressive cells, promote systemic T-cell responses and lymphocyte tra...

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Bibliographic Details
Main Authors: Jeffrey Schlom, Sofia R Gameiro, Karin M Knudson, Kristin C Hicks, Yohei Ozawa
Format: Article
Language:English
Published: BMJ Publishing Group 2020-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/8/1/e000493.full
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