3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models
Tissue engineering and in vitro modeling of the airways and lungs in the respiratory system are of substantial research and clinical importance. In vitro airway and lung models aim to improve treatment options for airway and lung repair and advance respiratory pathophysiological research. The constr...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-12-01
|
| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/20417314241309183 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846113384320204800 |
|---|---|
| author | Yanning Zhang Yujian Liu Chen Shu Yang Shen Mengchao Li Nan Ma Jinbo Zhao |
| author_facet | Yanning Zhang Yujian Liu Chen Shu Yang Shen Mengchao Li Nan Ma Jinbo Zhao |
| author_sort | Yanning Zhang |
| collection | DOAJ |
| description | Tissue engineering and in vitro modeling of the airways and lungs in the respiratory system are of substantial research and clinical importance. In vitro airway and lung models aim to improve treatment options for airway and lung repair and advance respiratory pathophysiological research. The construction of biomimetic native airways and lungs with tissue-specific biological, mechanical, and configurable features remains challenging. Bioprinting, an emerging 3D printing technology, is promising for the development of airway, lung, and disease models, allowing the incorporation of cells and biologically active molecules into printed constructs in a precise and reproducible manner to recreate the airways, lung architecture, and in vitro microenvironment. Herein, we present a review of airway and lung bioprinting for applications in tissue engineering and in vitro modeling. The key pathophysiological characteristics of the airway, lung interstitium, and alveoli are described. The bioinks recently used in 3D bioprinting of the airways and lungs are summarized. Furthermore, we propose a bioink categorization based on the structural characteristics of the lungs and airways. Finally, the challenges and opportunities in the research on biofabrication of airways and lungs are discussed. |
| format | Article |
| id | doaj-art-b97a0483e8f7496484b0dbb6062e5c32 |
| institution | Kabale University |
| issn | 2041-7314 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj-art-b97a0483e8f7496484b0dbb6062e5c322024-12-21T15:03:19ZengSAGE PublishingJournal of Tissue Engineering2041-73142024-12-011510.1177/204173142413091833D bioprinting of the airways and lungs for applications in tissue engineering and in vitro modelsYanning Zhang0Yujian Liu1Chen Shu2Yang Shen3Mengchao Li4Nan Ma5Jinbo Zhao6State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaDepartment of Cardiothoracic Surgery, Central Theater Command General Hospital of Chinese People’s Liberation Army, Wuhan, People’s Republic of ChinaDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi’an, People’s Republic of ChinaDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi’an, People’s Republic of ChinaDepartment of Medical Genetics and Cell Biology, School of Medicine, Yan’an University, Yan’an, People’s Republic of ChinaDepartment of Ophthalmology, The Second Affiliated Hospital, Air Force Medical University, Xi’an, People’s Republic of ChinaDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi’an, People’s Republic of ChinaTissue engineering and in vitro modeling of the airways and lungs in the respiratory system are of substantial research and clinical importance. In vitro airway and lung models aim to improve treatment options for airway and lung repair and advance respiratory pathophysiological research. The construction of biomimetic native airways and lungs with tissue-specific biological, mechanical, and configurable features remains challenging. Bioprinting, an emerging 3D printing technology, is promising for the development of airway, lung, and disease models, allowing the incorporation of cells and biologically active molecules into printed constructs in a precise and reproducible manner to recreate the airways, lung architecture, and in vitro microenvironment. Herein, we present a review of airway and lung bioprinting for applications in tissue engineering and in vitro modeling. The key pathophysiological characteristics of the airway, lung interstitium, and alveoli are described. The bioinks recently used in 3D bioprinting of the airways and lungs are summarized. Furthermore, we propose a bioink categorization based on the structural characteristics of the lungs and airways. Finally, the challenges and opportunities in the research on biofabrication of airways and lungs are discussed.https://doi.org/10.1177/20417314241309183 |
| spellingShingle | Yanning Zhang Yujian Liu Chen Shu Yang Shen Mengchao Li Nan Ma Jinbo Zhao 3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models Journal of Tissue Engineering |
| title | 3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models |
| title_full | 3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models |
| title_fullStr | 3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models |
| title_full_unstemmed | 3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models |
| title_short | 3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models |
| title_sort | 3d bioprinting of the airways and lungs for applications in tissue engineering and in vitro models |
| url | https://doi.org/10.1177/20417314241309183 |
| work_keys_str_mv | AT yanningzhang 3dbioprintingoftheairwaysandlungsforapplicationsintissueengineeringandinvitromodels AT yujianliu 3dbioprintingoftheairwaysandlungsforapplicationsintissueengineeringandinvitromodels AT chenshu 3dbioprintingoftheairwaysandlungsforapplicationsintissueengineeringandinvitromodels AT yangshen 3dbioprintingoftheairwaysandlungsforapplicationsintissueengineeringandinvitromodels AT mengchaoli 3dbioprintingoftheairwaysandlungsforapplicationsintissueengineeringandinvitromodels AT nanma 3dbioprintingoftheairwaysandlungsforapplicationsintissueengineeringandinvitromodels AT jinbozhao 3dbioprintingoftheairwaysandlungsforapplicationsintissueengineeringandinvitromodels |