Tissue sodium in patients with rheumatoid arthritis: a novel potential driver of hypertension in autoimmunity
Abstract Patients with rheumatoid arthritis (RA) have increased hypertension. Tissue sodium may contribute to development and progression of hypertension through immune cell activation. This study aimed to determine if skin sodium content is: 1) higher in RA versus control participants, and 2) assoc...
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| Format: | Article |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-83873-8 |
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| author | Carolina Ramirez-Becerra Annette M. Oeser Michael Pridmore Rachelle Crescenzi Jens M. Titze C. Michael Stein Michelle J. Ormseth |
| author_facet | Carolina Ramirez-Becerra Annette M. Oeser Michael Pridmore Rachelle Crescenzi Jens M. Titze C. Michael Stein Michelle J. Ormseth |
| author_sort | Carolina Ramirez-Becerra |
| collection | DOAJ |
| description | Abstract Patients with rheumatoid arthritis (RA) have increased hypertension. Tissue sodium may contribute to development and progression of hypertension through immune cell activation. This study aimed to determine if skin sodium content is: 1) higher in RA versus control participants, and 2) associated with blood pressure and disease activity. This cross-sectional study included 32 patients with RA and 33 control participants. Lower leg skin sodium content was measured using magnetic resonance imaging. Ambulatory 24-h blood pressure measurements were obtained, and disease activity was assessed by Disease Activity Score-28 for RA with CRP (DAS28-CRP). Skin sodium content was higher in RA versus control participants (14.22 [12.82, 18.04] vs 12.41 [10.67, 14.55] mmol/L), p = 0.005. Every 1 mmol/l increase in skin sodium was associated with a 1.05 mmHg (95% CI 0.29, 1.82 mmHg, p = 0.009) increase in average 24-h systolic blood pressure in patients with RA, but this relationship was not present in control participants. Skin sodium was not associated with DAS28-CRP or its components. Skin sodium is increased in RA versus control participants and is correlated with 24-h and diurnal systolic blood pressure in patients with RA but not in control participants. Skin sodium content may help explain increased hypertension in patients with RA. |
| format | Article |
| id | doaj-art-b9513845e1264c15b4330266261ad87a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-b9513845e1264c15b4330266261ad87a2025-01-05T12:29:20ZengNature PortfolioScientific Reports2045-23222024-12-011411810.1038/s41598-024-83873-8Tissue sodium in patients with rheumatoid arthritis: a novel potential driver of hypertension in autoimmunityCarolina Ramirez-Becerra0Annette M. Oeser1Michael Pridmore2Rachelle Crescenzi3Jens M. Titze4C. Michael Stein5Michelle J. Ormseth6Department of Medicine, Vanderbilt University Medical CenterDepartment of Medicine, Vanderbilt University Medical CenterDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical CenterDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical CenterProgramme in Cardiovascular and Metabolic Disorders, Duke-NUS Medical SchoolDepartment of Medicine, Vanderbilt University Medical CenterDepartment of Medicine, Vanderbilt University Medical CenterAbstract Patients with rheumatoid arthritis (RA) have increased hypertension. Tissue sodium may contribute to development and progression of hypertension through immune cell activation. This study aimed to determine if skin sodium content is: 1) higher in RA versus control participants, and 2) associated with blood pressure and disease activity. This cross-sectional study included 32 patients with RA and 33 control participants. Lower leg skin sodium content was measured using magnetic resonance imaging. Ambulatory 24-h blood pressure measurements were obtained, and disease activity was assessed by Disease Activity Score-28 for RA with CRP (DAS28-CRP). Skin sodium content was higher in RA versus control participants (14.22 [12.82, 18.04] vs 12.41 [10.67, 14.55] mmol/L), p = 0.005. Every 1 mmol/l increase in skin sodium was associated with a 1.05 mmHg (95% CI 0.29, 1.82 mmHg, p = 0.009) increase in average 24-h systolic blood pressure in patients with RA, but this relationship was not present in control participants. Skin sodium was not associated with DAS28-CRP or its components. Skin sodium is increased in RA versus control participants and is correlated with 24-h and diurnal systolic blood pressure in patients with RA but not in control participants. Skin sodium content may help explain increased hypertension in patients with RA.https://doi.org/10.1038/s41598-024-83873-8Rheumatoid arthritisSodiumHypertensionCardiovascular diseaseInflammation |
| spellingShingle | Carolina Ramirez-Becerra Annette M. Oeser Michael Pridmore Rachelle Crescenzi Jens M. Titze C. Michael Stein Michelle J. Ormseth Tissue sodium in patients with rheumatoid arthritis: a novel potential driver of hypertension in autoimmunity Scientific Reports Rheumatoid arthritis Sodium Hypertension Cardiovascular disease Inflammation |
| title | Tissue sodium in patients with rheumatoid arthritis: a novel potential driver of hypertension in autoimmunity |
| title_full | Tissue sodium in patients with rheumatoid arthritis: a novel potential driver of hypertension in autoimmunity |
| title_fullStr | Tissue sodium in patients with rheumatoid arthritis: a novel potential driver of hypertension in autoimmunity |
| title_full_unstemmed | Tissue sodium in patients with rheumatoid arthritis: a novel potential driver of hypertension in autoimmunity |
| title_short | Tissue sodium in patients with rheumatoid arthritis: a novel potential driver of hypertension in autoimmunity |
| title_sort | tissue sodium in patients with rheumatoid arthritis a novel potential driver of hypertension in autoimmunity |
| topic | Rheumatoid arthritis Sodium Hypertension Cardiovascular disease Inflammation |
| url | https://doi.org/10.1038/s41598-024-83873-8 |
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