Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain
Background:. Lipedema is a disease typically affecting women with a symmetrical, painful fat distribution disorder, which is hypothesized to be caused by impaired adipogenesis, inflammation, and extracellular matrix remodeling, leading to fibrosis and the development of edema in lipedema subcutaneou...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2024-11-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006288 |
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| author | Maria Karolin Streubel, PhD Axel Baumgartner, MD Ilka Meier-Vollrath, MD Yvonne Frambach, MD Matthias Brandenburger, PhD Tobias Kisch, MD |
| author_facet | Maria Karolin Streubel, PhD Axel Baumgartner, MD Ilka Meier-Vollrath, MD Yvonne Frambach, MD Matthias Brandenburger, PhD Tobias Kisch, MD |
| author_sort | Maria Karolin Streubel, PhD |
| collection | DOAJ |
| description | Background:. Lipedema is a disease typically affecting women with a symmetrical, painful fat distribution disorder, which is hypothesized to be caused by impaired adipogenesis, inflammation, and extracellular matrix remodeling, leading to fibrosis and the development of edema in lipedema subcutaneous adipose tissue. The pathogenesis and molecular processes leading to lipedema have not yet been clarified.
Methods:. A whole transcriptome analysis of subcutaneous tissue of lipedema stages I (n = 12), II (n = 9), and III (n = 8) compared with hypertrophied subcutaneous tissue (n = 4) was performed. Further data about hormonal substitution and body morphology were collected. The study is registered at ClinicalTrials.gov (NCT05861583).
Results:. We identified several differentially expressed genes involved in mechanisms leading to the development of lipedema. Some genes, such as PRKG2, MEDAG, CSF1R, BICC1, ERBB4, and ACP5, are involved in adipogenesis, regulating the development of mature adipocytes from mesenchymal stem cells. Other genes, such as MAFB, C1Q, C2, CD68, CD209, CD163, CD84, BCAT1, and TREM2, are predicted to be involved in lipid accumulation, hypertrophy, and the inflammation process. Further genes such as SHTN1, SCN7A, and SCL12A2 are predicted to be involved in the regulation and transmission of pain.
Conclusions:. In summary, the pathogenesis and development of lipedema might be caused by alterations in adipogenesis, inflammation, and extracellular matrix remodeling, leading to fibrosis and the formation of edema resulting in this painful disease. These processes differ from hypertrophied adipose tissue and may therefore play a main role in the formation of lipedema. |
| format | Article |
| id | doaj-art-b8bc402fb104410da9c4afd6fac2b08b |
| institution | Kabale University |
| issn | 2169-7574 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj-art-b8bc402fb104410da9c4afd6fac2b08b2024-11-26T08:02:35ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742024-11-011211e628810.1097/GOX.0000000000006288202411000-00022Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and PainMaria Karolin Streubel, PhD0Axel Baumgartner, MD1Ilka Meier-Vollrath, MD2Yvonne Frambach, MD3Matthias Brandenburger, PhD4Tobias Kisch, MD5From the * University of Luebeck, Luebeck, Germany‡ Hanse Clinic, Luebeck, Germany‡ Hanse Clinic, Luebeck, Germany‡ Hanse Clinic, Luebeck, Germany§ Fraunhofer Research Institution for Individualized and Cell Based Medical Engineering, IMTE, Luebeck, GermanyFrom the * University of Luebeck, Luebeck, GermanyBackground:. Lipedema is a disease typically affecting women with a symmetrical, painful fat distribution disorder, which is hypothesized to be caused by impaired adipogenesis, inflammation, and extracellular matrix remodeling, leading to fibrosis and the development of edema in lipedema subcutaneous adipose tissue. The pathogenesis and molecular processes leading to lipedema have not yet been clarified. Methods:. A whole transcriptome analysis of subcutaneous tissue of lipedema stages I (n = 12), II (n = 9), and III (n = 8) compared with hypertrophied subcutaneous tissue (n = 4) was performed. Further data about hormonal substitution and body morphology were collected. The study is registered at ClinicalTrials.gov (NCT05861583). Results:. We identified several differentially expressed genes involved in mechanisms leading to the development of lipedema. Some genes, such as PRKG2, MEDAG, CSF1R, BICC1, ERBB4, and ACP5, are involved in adipogenesis, regulating the development of mature adipocytes from mesenchymal stem cells. Other genes, such as MAFB, C1Q, C2, CD68, CD209, CD163, CD84, BCAT1, and TREM2, are predicted to be involved in lipid accumulation, hypertrophy, and the inflammation process. Further genes such as SHTN1, SCN7A, and SCL12A2 are predicted to be involved in the regulation and transmission of pain. Conclusions:. In summary, the pathogenesis and development of lipedema might be caused by alterations in adipogenesis, inflammation, and extracellular matrix remodeling, leading to fibrosis and the formation of edema resulting in this painful disease. These processes differ from hypertrophied adipose tissue and may therefore play a main role in the formation of lipedema.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006288 |
| spellingShingle | Maria Karolin Streubel, PhD Axel Baumgartner, MD Ilka Meier-Vollrath, MD Yvonne Frambach, MD Matthias Brandenburger, PhD Tobias Kisch, MD Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain Plastic and Reconstructive Surgery, Global Open |
| title | Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain |
| title_full | Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain |
| title_fullStr | Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain |
| title_full_unstemmed | Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain |
| title_short | Transcriptomics of Subcutaneous Tissue of Lipedema Identified Differentially Expressed Genes Involved in Adipogenesis, Inflammation, and Pain |
| title_sort | transcriptomics of subcutaneous tissue of lipedema identified differentially expressed genes involved in adipogenesis inflammation and pain |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000006288 |
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