Circulating T Cell Subsets in Type 1 Diabetes
Type 1 diabetes (T1D) is a complex disease driven by the immune system attacking the insulin-producing beta cells in the pancreas. Understanding the role of different T cell subpopulations in the development and progression of T1D is crucial. By employing flow cytometry to compare the characteristic...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/1/48 |
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| author | Aldo Ferreira-Hermosillo Paola Santana-Sánchez Ricardo Vaquero-García Manuel R. García-Sáenz Angélica Castro-Ríos Adriana K. Chávez-Rueda Rita A. Gómez-Díaz Luis Chávez-Sánchez María V. Legorreta-Haquet |
| author_facet | Aldo Ferreira-Hermosillo Paola Santana-Sánchez Ricardo Vaquero-García Manuel R. García-Sáenz Angélica Castro-Ríos Adriana K. Chávez-Rueda Rita A. Gómez-Díaz Luis Chávez-Sánchez María V. Legorreta-Haquet |
| author_sort | Aldo Ferreira-Hermosillo |
| collection | DOAJ |
| description | Type 1 diabetes (T1D) is a complex disease driven by the immune system attacking the insulin-producing beta cells in the pancreas. Understanding the role of different T cell subpopulations in the development and progression of T1D is crucial. By employing flow cytometry to compare the characteristics of T cells, we can pinpoint potential indicators of treatment response or therapeutic inefficacy. Our study reveals elevated prolactin (PRL) levels in T1D patients, along with a decreased production of key cytokines. Additionally, PD1 appears to play a significant role in T1D. Notably, PRL levels correlate with an earlier disease onset and a specific T cell phenotype, hinting at the potential influence of PRL. These findings highlight the need for further research to identify promising cellular targets for more effective and tailored therapies. |
| format | Article |
| id | doaj-art-b8849db941644c8686278ff8cf259293 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-b8849db941644c8686278ff8cf2592932025-01-10T13:16:21ZengMDPI AGCells2073-44092025-01-011414810.3390/cells14010048Circulating T Cell Subsets in Type 1 DiabetesAldo Ferreira-Hermosillo0Paola Santana-Sánchez1Ricardo Vaquero-García2Manuel R. García-Sáenz3Angélica Castro-Ríos4Adriana K. Chávez-Rueda5Rita A. Gómez-Díaz6Luis Chávez-Sánchez7María V. Legorreta-Haquet8Unidad de Investigación en Enfermedades Endócrinas de la UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoUnidad de Investigación Médica en Inmunología, de la UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoUnidad de Investigación Médica en Inmunología, de la UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoServicio de Endocrinología, de la UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoUnidad de Investigación en Epidemiología Clínica de la UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoUnidad de Investigación Médica en Inmunología, de la UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoUnidad de Investigación en Epidemiología Clínica de la UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoUnidad de Investigación Médica en Inmunología, de la UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoUnidad de Investigación Médica en Inmunología, de la UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoType 1 diabetes (T1D) is a complex disease driven by the immune system attacking the insulin-producing beta cells in the pancreas. Understanding the role of different T cell subpopulations in the development and progression of T1D is crucial. By employing flow cytometry to compare the characteristics of T cells, we can pinpoint potential indicators of treatment response or therapeutic inefficacy. Our study reveals elevated prolactin (PRL) levels in T1D patients, along with a decreased production of key cytokines. Additionally, PD1 appears to play a significant role in T1D. Notably, PRL levels correlate with an earlier disease onset and a specific T cell phenotype, hinting at the potential influence of PRL. These findings highlight the need for further research to identify promising cellular targets for more effective and tailored therapies.https://www.mdpi.com/2073-4409/14/1/48type 1 diabetesPD1PRLT cells |
| spellingShingle | Aldo Ferreira-Hermosillo Paola Santana-Sánchez Ricardo Vaquero-García Manuel R. García-Sáenz Angélica Castro-Ríos Adriana K. Chávez-Rueda Rita A. Gómez-Díaz Luis Chávez-Sánchez María V. Legorreta-Haquet Circulating T Cell Subsets in Type 1 Diabetes Cells type 1 diabetes PD1 PRL T cells |
| title | Circulating T Cell Subsets in Type 1 Diabetes |
| title_full | Circulating T Cell Subsets in Type 1 Diabetes |
| title_fullStr | Circulating T Cell Subsets in Type 1 Diabetes |
| title_full_unstemmed | Circulating T Cell Subsets in Type 1 Diabetes |
| title_short | Circulating T Cell Subsets in Type 1 Diabetes |
| title_sort | circulating t cell subsets in type 1 diabetes |
| topic | type 1 diabetes PD1 PRL T cells |
| url | https://www.mdpi.com/2073-4409/14/1/48 |
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