Acquired Methemoglobinemia After Application of Prilocaine
Prilocaine is a local anesthetic agent and is widely used in most of ambulatory procedures, but it can cause methemoglobinemia which is a life-threatening condition. Methemoglobinemia may cause hypoxia of tissue because methemoglobin has less oxygen carrying capability than hemoglobin. A 54-day-old...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2014-04-01
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| Series: | Güncel Pediatri |
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| Online Access: | http://dx.doi.org/10.4274/jcp.84803 |
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| author | Çapan Konca Zelal Kahramaner Mehmet Çoban |
| author_facet | Çapan Konca Zelal Kahramaner Mehmet Çoban |
| author_sort | Çapan Konca |
| collection | DOAJ |
| description | Prilocaine is a local anesthetic agent and is widely used in most of ambulatory procedures, but it can cause methemoglobinemia which is a life-threatening condition. Methemoglobinemia may cause hypoxia of tissue because methemoglobin has less oxygen carrying capability than hemoglobin. A 54-day-old boy who developed cyanosis around his mouth, on his hands and toes two hours after the circumcision operation was admitted to the emergency department. No abnormality was established on his physical examination except for cyanosis. Cyanosis did not improve with oxygen administration and the patient was admitted to intensive care unit. His history revealed that prilocaine hydrochloride (2 mg/kg) was administered subcutaneously as local anesthesia prior to circumcision operation. Diagnosis of methemoglobinemia was established in the patient in whom saturation levels were low in spite of the oxygen therapy and in whom methemoglobinemia level was 24.7%. His cyanosis completely disappeared after administration of intravenous ascorbic acid (300 mg/kg/dose) and he was discharged after a 24-hour follow-up period with recovery. Methemoglobinemia should be considered in cases with cyanosis and inconsistency between oxygen saturation and partial arterial oxygen pressure. These cases should be monitored in pediatric intensive care units for lethal complications. (The Journal of Current Pediatrics 2014;1:54-7) |
| format | Article |
| id | doaj-art-b883580e8fb54c88892b7b204c8a9aa9 |
| institution | Kabale University |
| issn | 1304-9054 |
| language | English |
| publishDate | 2014-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Güncel Pediatri |
| spelling | doaj-art-b883580e8fb54c88892b7b204c8a9aa92025-01-02T18:25:43ZengGalenos Publishing HouseGüncel Pediatri1304-90542014-04-01121545710.4274/jcp.84803Acquired Methemoglobinemia After Application of PrilocaineÇapan Konca0 Zelal Kahramaner1Mehmet Çoban2Adıyaman Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Yoğun Bakım Ünitesi, Adıyaman, TürkiyeAdıyaman Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Adıyaman, TürkiyeAdıyaman Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Adıyaman, TürkiyePrilocaine is a local anesthetic agent and is widely used in most of ambulatory procedures, but it can cause methemoglobinemia which is a life-threatening condition. Methemoglobinemia may cause hypoxia of tissue because methemoglobin has less oxygen carrying capability than hemoglobin. A 54-day-old boy who developed cyanosis around his mouth, on his hands and toes two hours after the circumcision operation was admitted to the emergency department. No abnormality was established on his physical examination except for cyanosis. Cyanosis did not improve with oxygen administration and the patient was admitted to intensive care unit. His history revealed that prilocaine hydrochloride (2 mg/kg) was administered subcutaneously as local anesthesia prior to circumcision operation. Diagnosis of methemoglobinemia was established in the patient in whom saturation levels were low in spite of the oxygen therapy and in whom methemoglobinemia level was 24.7%. His cyanosis completely disappeared after administration of intravenous ascorbic acid (300 mg/kg/dose) and he was discharged after a 24-hour follow-up period with recovery. Methemoglobinemia should be considered in cases with cyanosis and inconsistency between oxygen saturation and partial arterial oxygen pressure. These cases should be monitored in pediatric intensive care units for lethal complications. (The Journal of Current Pediatrics 2014;1:54-7)http://dx.doi.org/10.4274/jcp.84803Childhoodmethemoglobinemiaapplication of prilocain |
| spellingShingle | Çapan Konca Zelal Kahramaner Mehmet Çoban Acquired Methemoglobinemia After Application of Prilocaine Güncel Pediatri Childhood methemoglobinemia application of prilocain |
| title | Acquired Methemoglobinemia After Application of Prilocaine |
| title_full | Acquired Methemoglobinemia After Application of Prilocaine |
| title_fullStr | Acquired Methemoglobinemia After Application of Prilocaine |
| title_full_unstemmed | Acquired Methemoglobinemia After Application of Prilocaine |
| title_short | Acquired Methemoglobinemia After Application of Prilocaine |
| title_sort | acquired methemoglobinemia after application of prilocaine |
| topic | Childhood methemoglobinemia application of prilocain |
| url | http://dx.doi.org/10.4274/jcp.84803 |
| work_keys_str_mv | AT capankonca acquiredmethemoglobinemiaafterapplicationofprilocaine AT zelalkahramaner acquiredmethemoglobinemiaafterapplicationofprilocaine AT mehmetcoban acquiredmethemoglobinemiaafterapplicationofprilocaine |