Insights from in vivo preclinical cancer studies with histotripsy
Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technique that mechanically fractionates target tissue into acellular homogenate via controlled acoustic cavitation. Histotripsy has been evaluated for various preclinical applications requiring noninvasive tissue removal i...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2023.2297650 |
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| author | Tejaswi Worlikar Timothy Hall Man Zhang Mishal Mendiratta-Lala Michael Green Clifford S. Cho Zhen Xu |
| author_facet | Tejaswi Worlikar Timothy Hall Man Zhang Mishal Mendiratta-Lala Michael Green Clifford S. Cho Zhen Xu |
| author_sort | Tejaswi Worlikar |
| collection | DOAJ |
| description | Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technique that mechanically fractionates target tissue into acellular homogenate via controlled acoustic cavitation. Histotripsy has been evaluated for various preclinical applications requiring noninvasive tissue removal including cancer, brain surgery, blood clot and hematoma liquefaction, and correction of neonatal congenital heart defects. Promising preclinical results including local tumor suppression, improved survival outcomes, local and systemic anti-tumor immune responses, and histotripsy-induced abscopal effects have been reported in various animal tumor models. Histotripsy is also being investigated in veterinary patients with spontaneously arising tumors. Research is underway to combine histotripsy with immunotherapy and chemotherapy to improve therapeutic outcomes. In addition to preclinical cancer research, human clinical trials are ongoing for the treatment of liver tumors and renal tumors. Histotripsy has been recently approved by the FDA for noninvasive treatment of liver tumors. This review highlights key learnings from in vivo shock-scattering histotripsy, intrinsic threshold histotripsy, and boiling histotripsy cancer studies treating cancers of different anatomic locations and discusses the major considerations in planning in vivo histotripsy studies regarding instrumentation, tumor model, study design, treatment dose, and post-treatment tumor monitoring. |
| format | Article |
| id | doaj-art-b87cec0cc9804af68fc00d095f3e28b5 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-b87cec0cc9804af68fc00d095f3e28b52025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2023.2297650Insights from in vivo preclinical cancer studies with histotripsyTejaswi Worlikar0Timothy Hall1Man Zhang2Mishal Mendiratta-Lala3Michael Green4Clifford S. Cho5Zhen Xu6Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USADepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USADepartment of Radiology, University of Michigan, Ann Arbor, MI, USADepartment of Radiology, University of Michigan, Ann Arbor, MI, USADepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USADepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, USADepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USAHistotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technique that mechanically fractionates target tissue into acellular homogenate via controlled acoustic cavitation. Histotripsy has been evaluated for various preclinical applications requiring noninvasive tissue removal including cancer, brain surgery, blood clot and hematoma liquefaction, and correction of neonatal congenital heart defects. Promising preclinical results including local tumor suppression, improved survival outcomes, local and systemic anti-tumor immune responses, and histotripsy-induced abscopal effects have been reported in various animal tumor models. Histotripsy is also being investigated in veterinary patients with spontaneously arising tumors. Research is underway to combine histotripsy with immunotherapy and chemotherapy to improve therapeutic outcomes. In addition to preclinical cancer research, human clinical trials are ongoing for the treatment of liver tumors and renal tumors. Histotripsy has been recently approved by the FDA for noninvasive treatment of liver tumors. This review highlights key learnings from in vivo shock-scattering histotripsy, intrinsic threshold histotripsy, and boiling histotripsy cancer studies treating cancers of different anatomic locations and discusses the major considerations in planning in vivo histotripsy studies regarding instrumentation, tumor model, study design, treatment dose, and post-treatment tumor monitoring.https://www.tandfonline.com/doi/10.1080/02656736.2023.2297650Histotripsycancerboiling histotripsypreclinicalimmune effectsin vivo |
| spellingShingle | Tejaswi Worlikar Timothy Hall Man Zhang Mishal Mendiratta-Lala Michael Green Clifford S. Cho Zhen Xu Insights from in vivo preclinical cancer studies with histotripsy International Journal of Hyperthermia Histotripsy cancer boiling histotripsy preclinical immune effects in vivo |
| title | Insights from in vivo preclinical cancer studies with histotripsy |
| title_full | Insights from in vivo preclinical cancer studies with histotripsy |
| title_fullStr | Insights from in vivo preclinical cancer studies with histotripsy |
| title_full_unstemmed | Insights from in vivo preclinical cancer studies with histotripsy |
| title_short | Insights from in vivo preclinical cancer studies with histotripsy |
| title_sort | insights from in vivo preclinical cancer studies with histotripsy |
| topic | Histotripsy cancer boiling histotripsy preclinical immune effects in vivo |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2023.2297650 |
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