The establishment of an expected concentration reference range for eltrombopag in the individualized treatment of pediatric immune thrombocytopenia

The establishment of an expected concentration reference range for eltrombopag in the individualized treatment of pediatric immune thrombocytopenia

BackgroundDifferences in the clinical efficacy and adverse drug reactions (ADRs) of eltrombopag (ELT) in children with immune thrombocytopenia (ITP) may be positively correlated with the serum trough concentration of ELT. Individual pharmacokinetic variations primarily contribute to differences in E...

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Bibliographic Details
Main Authors: Nan Wang, Shuyue Dong, Yixin Sun, Jingjing Liu, Zhifa Wang, Jingyao Ma, Xiaoling Wang, Runhui Wu, Xiaoling Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
eltrombopag
immune thrombocytopenia
children
individualized treatment
therapeutic drug monitoring
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1597641/full
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