Progress on long non-coding RNAs in calcific aortic valve disease
Calcific aortic valve disease (CAVD) is a common cardiovascular condition in the elderly population. The aortic valve, influenced by factors such as endothelial dysfunction, inflammation, oxidative stress, lipid metabolism disorders, calcium deposition, and extracellular matrix remodeling, undergoes...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1522544/full |
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| author | Yan Shen Jiahui Li Zehao Zhao Xiaomin Chen |
| author_facet | Yan Shen Jiahui Li Zehao Zhao Xiaomin Chen |
| author_sort | Yan Shen |
| collection | DOAJ |
| description | Calcific aortic valve disease (CAVD) is a common cardiovascular condition in the elderly population. The aortic valve, influenced by factors such as endothelial dysfunction, inflammation, oxidative stress, lipid metabolism disorders, calcium deposition, and extracellular matrix remodeling, undergoes fibrosis and calcification, ultimately leading to stenosis. In recent years, long non-coding RNAs (lncRNAs) have emerged as significant regulators of gene expression, playing crucial roles in the occurrence and progression of various diseases. Research has shown that lncRNAs participate in the pathological process underlying CAVD by regulating osteogenic differentiation and inflammatory response of valve interstitial cells. Specifically, lncRNAs, such as H19, MALAT1, and TUG1, are closely associated with CAVD. Some lncRNAs can act as miRNA sponges, form complex regulatory networks, and modulate the expression of calcification-related genes. In brief, this review discusses the mechanisms and potential therapeutic targets of lncRNAs in CAVD. |
| format | Article |
| id | doaj-art-b85e84eba2d54208a8caba8252957508 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-b85e84eba2d54208a8caba82529575082025-01-17T06:50:34ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011210.3389/fcvm.2025.15225441522544Progress on long non-coding RNAs in calcific aortic valve diseaseYan Shen0Jiahui Li1Zehao Zhao2Xiaomin Chen3Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, ChinaDepartment of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, ChinaDepartment of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, ChinaCalcific aortic valve disease (CAVD) is a common cardiovascular condition in the elderly population. The aortic valve, influenced by factors such as endothelial dysfunction, inflammation, oxidative stress, lipid metabolism disorders, calcium deposition, and extracellular matrix remodeling, undergoes fibrosis and calcification, ultimately leading to stenosis. In recent years, long non-coding RNAs (lncRNAs) have emerged as significant regulators of gene expression, playing crucial roles in the occurrence and progression of various diseases. Research has shown that lncRNAs participate in the pathological process underlying CAVD by regulating osteogenic differentiation and inflammatory response of valve interstitial cells. Specifically, lncRNAs, such as H19, MALAT1, and TUG1, are closely associated with CAVD. Some lncRNAs can act as miRNA sponges, form complex regulatory networks, and modulate the expression of calcification-related genes. In brief, this review discusses the mechanisms and potential therapeutic targets of lncRNAs in CAVD.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1522544/fullcalcific aortic valve diseaselong non-coding RNAvalve interstitial cellsosteogenic differentiationmechanisms |
| spellingShingle | Yan Shen Jiahui Li Zehao Zhao Xiaomin Chen Progress on long non-coding RNAs in calcific aortic valve disease Frontiers in Cardiovascular Medicine calcific aortic valve disease long non-coding RNA valve interstitial cells osteogenic differentiation mechanisms |
| title | Progress on long non-coding RNAs in calcific aortic valve disease |
| title_full | Progress on long non-coding RNAs in calcific aortic valve disease |
| title_fullStr | Progress on long non-coding RNAs in calcific aortic valve disease |
| title_full_unstemmed | Progress on long non-coding RNAs in calcific aortic valve disease |
| title_short | Progress on long non-coding RNAs in calcific aortic valve disease |
| title_sort | progress on long non coding rnas in calcific aortic valve disease |
| topic | calcific aortic valve disease long non-coding RNA valve interstitial cells osteogenic differentiation mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1522544/full |
| work_keys_str_mv | AT yanshen progressonlongnoncodingrnasincalcificaorticvalvedisease AT jiahuili progressonlongnoncodingrnasincalcificaorticvalvedisease AT zehaozhao progressonlongnoncodingrnasincalcificaorticvalvedisease AT xiaominchen progressonlongnoncodingrnasincalcificaorticvalvedisease |