Surfactant Protein-D (SP-D) serum levels as a predictor of COVID-19 severity and mortality: A systematic review and meta-analysis
Introduction: This study investigates the diagnostic and prognostic potential of Surfactant Protein D (SP-D), in distinguishing COVID-19 patients from healthy controls and predicting outcomes in infected individuals. Through a comprehensive systematic review and meta-analysis, we aim to elucidate th...
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International Network for the Advancement of Medicine, Psychology, and Public Health (INAMPPH)
2024-10-01
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| Series: | Advances in Medicine, Psychology, and Public Health |
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| Online Access: | https://ampphealthjournal-network.org/wp-content/uploads/2024/04/AMPPH_2024_-174_184.pdf |
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| _version_ | 1846148627175571456 |
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| author | Kacper Dziedzic Michal Pruc Gabriella Nucera Damian Swieczkowski Maciej Koselak Lukasz Szarpak |
| author_facet | Kacper Dziedzic Michal Pruc Gabriella Nucera Damian Swieczkowski Maciej Koselak Lukasz Szarpak |
| author_sort | Kacper Dziedzic |
| collection | DOAJ |
| description | Introduction: This study investigates the diagnostic and prognostic potential of Surfactant Protein D (SP-D), in distinguishing COVID-19 patients from healthy controls and predicting outcomes in infected individuals. Through a comprehensive systematic review and meta-analysis, we aim to elucidate the role of SP-D in the clinical management of COVID-19, addressing a crucial gap in current biomarker research.
Methods: We searched PubMed, Embase, Web of Science, and Scopus, for articles published in English up to January 21, 2024. We employed a systematic review and meta-analysis approach, searching multiple databases for studies that measured SP-D levels in COVID-19 patients and healthy controls. The inclusion criteria were strictly defined to ensure the selection of studies with high-quality data, and statistical analyses were performed to assess the
diagnostic and prognostic value of SP-D in the context of COVID-19.
Results: Twelve studies were included in this systematic review and meta-analysis. Pooled analysis showed that SP-D levels among those groups of patients varied and amounted to 44.38±74.71 vs. 21.29±31.8, respectively (SMD = 1.39; 95%CI: 0.35 to 2.43; p=0.009). Pooled analysis of SP-D values among severe and non-severe COVID-19 patients was 58.28±101.8 and 94.69±114.22 respectively (SMD = 0.44; 95%CI: -0.78 to 1.66; p=0.48). SP-D levels also did not detect statistically significant differences in COVID-19 patients who survived and died in the hospital (27.18±16.4 vs. 29.12±14.14; SMD = 0.07; 95%CI: -0.28 to 0.42; p=0.70).
Conclusions: Results of the current systematic review and meta-analysis indicated that SP-D may be a good marker for differentiating patients with COVID-19 from healthy patients, but
it does not provide prognostic value among patients with COVID-19. Further studies are needed to confirm the results |
| format | Article |
| id | doaj-art-b85435ea62aa4a7981994e5f2a45959d |
| institution | Kabale University |
| issn | 3034-8803 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | International Network for the Advancement of Medicine, Psychology, and Public Health (INAMPPH) |
| record_format | Article |
| series | Advances in Medicine, Psychology, and Public Health |
| spelling | doaj-art-b85435ea62aa4a7981994e5f2a45959d2024-11-30T21:51:02ZengInternational Network for the Advancement of Medicine, Psychology, and Public Health (INAMPPH)Advances in Medicine, Psychology, and Public Health3034-88032024-10-011417418410.5281/zenodo.11075270Surfactant Protein-D (SP-D) serum levels as a predictor of COVID-19 severity and mortality: A systematic review and meta-analysisKacper Dziedzic 0https://orcid.org/0000-0001-8930-2221Michal Pruc1https://orcid.org/0000-0002-2140-9732Gabriella Nucera2https://orcid.org/0000-0003-1425-0046Damian Swieczkowski3https://orcid.org/0000-0002-5648-4652Maciej Koselak4https://orcid.org/0000-0003-3945-4344Lukasz Szarpak5https://orcid.org/0000-0002-0973-5455Department of Clinical Research and Development, LUXMED Group, Warsaw, PolandDepartment of Clinical Research and Development, LUXMED Group, Warsaw, Poland; Department of Public Health, International European University, Kyiv, UkraineFatebenefratelli Hospital, Milano, ItalyDepartment of Toxicology, Faculty of Pharmacy, Medical University of Gdansk, Poland; Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland.Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Warsaw, PolandDepartment of Clinical Research and Development, LUXMED Group, Warsaw, Poland; Research Unit, Maria Sklodowska-Curie Bialystok Oncology Center, Warsaw, Poland; Institute of Outcomes Research, Maria Sklodowska-Curie, Warsaaw, Poland; Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USAIntroduction: This study investigates the diagnostic and prognostic potential of Surfactant Protein D (SP-D), in distinguishing COVID-19 patients from healthy controls and predicting outcomes in infected individuals. Through a comprehensive systematic review and meta-analysis, we aim to elucidate the role of SP-D in the clinical management of COVID-19, addressing a crucial gap in current biomarker research. Methods: We searched PubMed, Embase, Web of Science, and Scopus, for articles published in English up to January 21, 2024. We employed a systematic review and meta-analysis approach, searching multiple databases for studies that measured SP-D levels in COVID-19 patients and healthy controls. The inclusion criteria were strictly defined to ensure the selection of studies with high-quality data, and statistical analyses were performed to assess the diagnostic and prognostic value of SP-D in the context of COVID-19. Results: Twelve studies were included in this systematic review and meta-analysis. Pooled analysis showed that SP-D levels among those groups of patients varied and amounted to 44.38±74.71 vs. 21.29±31.8, respectively (SMD = 1.39; 95%CI: 0.35 to 2.43; p=0.009). Pooled analysis of SP-D values among severe and non-severe COVID-19 patients was 58.28±101.8 and 94.69±114.22 respectively (SMD = 0.44; 95%CI: -0.78 to 1.66; p=0.48). SP-D levels also did not detect statistically significant differences in COVID-19 patients who survived and died in the hospital (27.18±16.4 vs. 29.12±14.14; SMD = 0.07; 95%CI: -0.28 to 0.42; p=0.70). Conclusions: Results of the current systematic review and meta-analysis indicated that SP-D may be a good marker for differentiating patients with COVID-19 from healthy patients, but it does not provide prognostic value among patients with COVID-19. Further studies are needed to confirm the resultshttps://ampphealthjournal-network.org/wp-content/uploads/2024/04/AMPPH_2024_-174_184.pdfardscovid-19meta-analysismortalitysurfactant protein-dseverity |
| spellingShingle | Kacper Dziedzic Michal Pruc Gabriella Nucera Damian Swieczkowski Maciej Koselak Lukasz Szarpak Surfactant Protein-D (SP-D) serum levels as a predictor of COVID-19 severity and mortality: A systematic review and meta-analysis Advances in Medicine, Psychology, and Public Health ards covid-19 meta-analysis mortality surfactant protein-d severity |
| title | Surfactant Protein-D (SP-D) serum levels as a predictor of COVID-19 severity and mortality: A systematic review and meta-analysis |
| title_full | Surfactant Protein-D (SP-D) serum levels as a predictor of COVID-19 severity and mortality: A systematic review and meta-analysis |
| title_fullStr | Surfactant Protein-D (SP-D) serum levels as a predictor of COVID-19 severity and mortality: A systematic review and meta-analysis |
| title_full_unstemmed | Surfactant Protein-D (SP-D) serum levels as a predictor of COVID-19 severity and mortality: A systematic review and meta-analysis |
| title_short | Surfactant Protein-D (SP-D) serum levels as a predictor of COVID-19 severity and mortality: A systematic review and meta-analysis |
| title_sort | surfactant protein d sp d serum levels as a predictor of covid 19 severity and mortality a systematic review and meta analysis |
| topic | ards covid-19 meta-analysis mortality surfactant protein-d severity |
| url | https://ampphealthjournal-network.org/wp-content/uploads/2024/04/AMPPH_2024_-174_184.pdf |
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