Pathogenic effects of telomerase reverse transcriptase (TERT) promoter mutations in nonalcoholic steatohepatitis (NASH) related hepatocellular carcinoma (HCC) and its potentials as a diagnostic biomarker

Pathogenic effects of telomerase reverse transcriptase (TERT) promoter mutations in nonalcoholic steatohepatitis (NASH) related hepatocellular carcinoma (HCC) and its potentials as a diagnostic biomarker

Abstract Background Hepatocellular carcinoma (HCC) is the most common type of liver cancer globally due to its diverse aetiologies, poor diagnosis and prognosis as well as low survival rate. Nonalcoholic steatohepatitis-related HCC (NASH-HCC), the progressive form of nonalcoholic fatty liver, is the...

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Main Authors: Usman Umar Liman, Asanka Sudeshini Hawage, Sumadee De Silva, Saumya Madushani Samarasinghe, Kamani Hemamala Tennekoon, Rohan Chaminda Siriwardana, Madunil Anuk Niriella
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Hepatocellular carcinoma (HCC)
NAFLD
NASH-HCC
Telomeres
TERT gene
TERT promoter mutations
Online Access:https://doi.org/10.1186/s43042-025-00738-z
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https://doi.org/10.1186/s43042-025-00738-z

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