Advances in retina genetics: Progress, potential, and challenges
The field of retinal genetics has seen remarkable advancements lately, reshaping our understanding of various retinal conditions, including age-related macular degeneration, diabetic retinopathy, and inherited retinal dystrophies. The purpose of this review is to provide an overview of the current s...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
|
| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_3334_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841556819359563776 |
|---|---|
| author | Mayank Bansal |
| author_facet | Mayank Bansal |
| author_sort | Mayank Bansal |
| collection | DOAJ |
| description | The field of retinal genetics has seen remarkable advancements lately, reshaping our understanding of various retinal conditions, including age-related macular degeneration, diabetic retinopathy, and inherited retinal dystrophies. The purpose of this review is to provide an overview of the current status of genetics in the retina, covering the progress made, the expected future developments, and the challenges yet to be overcome. We highlight key advancements such as the advent of next-generation sequencing, which has exponentially enhanced the discovery of genetic mutations, thus also enabling personalized medicine/therapeutic approaches. Stem cells, gene augmentation, and gene-editing techniques such as CRISPR/Cas9 are discussed, in which we highlight ongoing research as well as their potential in the targeted treatment of retinal diseases. Despite these promising advancements, the field faces significant challenges, such as the complex interpretation of genetic data, ethical considerations, and the translational gap from bench to bedside. This review serves as a comprehensive guide not only to ophthalmologists but also to other healthcare professionals, scientists, and policymakers, providing insights into the rapidly evolving landscape of retinal genetics. It aims to stimulate further research and collaboration to surmount existing challenges and harness the full potential of genetic advancements for retinal health. |
| format | Article |
| id | doaj-art-b7e0a243e92f492290fceebf79dd4a7c |
| institution | Kabale University |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-b7e0a243e92f492290fceebf79dd4a7c2025-01-07T06:28:38ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892025-01-0173Suppl 1S31S3610.4103/IJO.IJO_3334_23Advances in retina genetics: Progress, potential, and challengesMayank BansalThe field of retinal genetics has seen remarkable advancements lately, reshaping our understanding of various retinal conditions, including age-related macular degeneration, diabetic retinopathy, and inherited retinal dystrophies. The purpose of this review is to provide an overview of the current status of genetics in the retina, covering the progress made, the expected future developments, and the challenges yet to be overcome. We highlight key advancements such as the advent of next-generation sequencing, which has exponentially enhanced the discovery of genetic mutations, thus also enabling personalized medicine/therapeutic approaches. Stem cells, gene augmentation, and gene-editing techniques such as CRISPR/Cas9 are discussed, in which we highlight ongoing research as well as their potential in the targeted treatment of retinal diseases. Despite these promising advancements, the field faces significant challenges, such as the complex interpretation of genetic data, ethical considerations, and the translational gap from bench to bedside. This review serves as a comprehensive guide not only to ophthalmologists but also to other healthcare professionals, scientists, and policymakers, providing insights into the rapidly evolving landscape of retinal genetics. It aims to stimulate further research and collaboration to surmount existing challenges and harness the full potential of genetic advancements for retinal health.https://journals.lww.com/10.4103/IJO.IJO_3334_23age-related macular degenerationclustered regularly interspaced short palindromic repeatsdiabetic retinopathygene augmentationinherited retinal dystrophiesnext-generation sequencingpersonalized medicineretinal geneticsstem cells |
| spellingShingle | Mayank Bansal Advances in retina genetics: Progress, potential, and challenges Indian Journal of Ophthalmology age-related macular degeneration clustered regularly interspaced short palindromic repeats diabetic retinopathy gene augmentation inherited retinal dystrophies next-generation sequencing personalized medicine retinal genetics stem cells |
| title | Advances in retina genetics: Progress, potential, and challenges |
| title_full | Advances in retina genetics: Progress, potential, and challenges |
| title_fullStr | Advances in retina genetics: Progress, potential, and challenges |
| title_full_unstemmed | Advances in retina genetics: Progress, potential, and challenges |
| title_short | Advances in retina genetics: Progress, potential, and challenges |
| title_sort | advances in retina genetics progress potential and challenges |
| topic | age-related macular degeneration clustered regularly interspaced short palindromic repeats diabetic retinopathy gene augmentation inherited retinal dystrophies next-generation sequencing personalized medicine retinal genetics stem cells |
| url | https://journals.lww.com/10.4103/IJO.IJO_3334_23 |
| work_keys_str_mv | AT mayankbansal advancesinretinageneticsprogresspotentialandchallenges |