Prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia: protocol for a cohort study
Introduction The association between chronic widespread pain (CWP) and disability is well established. Although research support large interindividual differences in functional outcomes, limited studies are available on the socio-economic consequences of offering stratified treatment based on progno...
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BMJ Publishing Group
2021-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/12/e052919.full |
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| author | Robin Christensen Marius Henriksen Eva Ejlersen Wæhrens Henning Bliddal Lars Erik Kristensen Karsten Thielen Henning Locht Kirstine Amris Pernille H Duhn |
| author_facet | Robin Christensen Marius Henriksen Eva Ejlersen Wæhrens Henning Bliddal Lars Erik Kristensen Karsten Thielen Henning Locht Kirstine Amris Pernille H Duhn |
| author_sort | Robin Christensen |
| collection | DOAJ |
| description | Introduction The association between chronic widespread pain (CWP) and disability is well established. Although research support large interindividual differences in functional outcomes, limited studies are available on the socio-economic consequences of offering stratified treatment based on prognostic factors. Identification of predictors of long-term functional outcomes such as work disability as a critical consequence, could assist early and targeted personalised interventions. The primary objective of this cohort study is to identify prognostic factors for the primary endpoint work status (employed and working vs not working) in patients with CWP assessed 3 years from baseline, that is, at referral for specialist care.Methods and analyses Data are collected at the diagnostic unit at Department of Rheumatology, Frederiksberg Hospital. The first 1000 patients ≥18 years of age registered in a clinical research database (DANFIB registry) with CWP either ‘employed and working’ or ‘not working’ will be enrolled. Participants must meet the American College of Rheumatology 1990 definition of CWP, that is, pain in all four body quadrants and axially for more than 3 months and are additionally screened for fulfilment of criteria for fibromyalgia. Clinical data and patient-reported outcomes are collected at referral (baseline) through clinical assessment and electronic questionnaires. Data on the primary endpoint work status at baseline and 3 years from baseline will be extracted from the Integrated Labour Market Database, Statistics Denmark and the nationwide Danish DREAM database. Prognostic factor analysis will be based on multivariable logistic regression modelling with the dichotomous work status as dependent variable.Ethics and dissemination Sensitive personal data will be anonymised according to regulations by the Danish Data Protection Agency, and informed consent are obtained from all participants. Understanding and improving the prognosis of a health condition like CWP should be a priority in clinical research and practice. Results will be published in international peer-reviewed journals.Trial registration number NCT04862520. |
| format | Article |
| id | doaj-art-b7d43b93403f4e9dac1c6012ab78c64a |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-b7d43b93403f4e9dac1c6012ab78c64a2024-12-11T02:45:13ZengBMJ Publishing GroupBMJ Open2044-60552021-12-01111210.1136/bmjopen-2021-052919Prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia: protocol for a cohort studyRobin Christensen0Marius Henriksen1Eva Ejlersen Wæhrens2Henning Bliddal3Lars Erik Kristensen4Karsten Thielen5Henning Locht6Kirstine Amris7Pernille H Duhn8Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen and Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, DenmarkThe Parker Institute, Frederiksberg, Copenhagen University Hospital, Frederiksberg, DenmarkOccupational Science & Occupational Therapy, User Perspectives and Community-Based Research, Department of Public Health, University of Southern Denmark, Odense, Denmark3Rheumatology and Radiology departments at hospitals at Zealand, Jutland and Funen, Copenhagen, Slagelse, Aarhus, Silkeborg, Odense, Hjørring and Graasten, DenmarkRheumatology, Frederiksberg Hospital, Frederiksberg, DenmarkDepartment of Social Medicine, University of Copenhagen, Kobenhavn, DenmarkRheumatology, Frederiksberg Hospital, Frederiksberg, DenmarkThe Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Frederiksberg, DenmarkParker Institute, Frederiksberg Hospital, Frederiksberg, DenmarkIntroduction The association between chronic widespread pain (CWP) and disability is well established. Although research support large interindividual differences in functional outcomes, limited studies are available on the socio-economic consequences of offering stratified treatment based on prognostic factors. Identification of predictors of long-term functional outcomes such as work disability as a critical consequence, could assist early and targeted personalised interventions. The primary objective of this cohort study is to identify prognostic factors for the primary endpoint work status (employed and working vs not working) in patients with CWP assessed 3 years from baseline, that is, at referral for specialist care.Methods and analyses Data are collected at the diagnostic unit at Department of Rheumatology, Frederiksberg Hospital. The first 1000 patients ≥18 years of age registered in a clinical research database (DANFIB registry) with CWP either ‘employed and working’ or ‘not working’ will be enrolled. Participants must meet the American College of Rheumatology 1990 definition of CWP, that is, pain in all four body quadrants and axially for more than 3 months and are additionally screened for fulfilment of criteria for fibromyalgia. Clinical data and patient-reported outcomes are collected at referral (baseline) through clinical assessment and electronic questionnaires. Data on the primary endpoint work status at baseline and 3 years from baseline will be extracted from the Integrated Labour Market Database, Statistics Denmark and the nationwide Danish DREAM database. Prognostic factor analysis will be based on multivariable logistic regression modelling with the dichotomous work status as dependent variable.Ethics and dissemination Sensitive personal data will be anonymised according to regulations by the Danish Data Protection Agency, and informed consent are obtained from all participants. Understanding and improving the prognosis of a health condition like CWP should be a priority in clinical research and practice. Results will be published in international peer-reviewed journals.Trial registration number NCT04862520.https://bmjopen.bmj.com/content/11/12/e052919.full |
| spellingShingle | Robin Christensen Marius Henriksen Eva Ejlersen Wæhrens Henning Bliddal Lars Erik Kristensen Karsten Thielen Henning Locht Kirstine Amris Pernille H Duhn Prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia: protocol for a cohort study BMJ Open |
| title | Prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia: protocol for a cohort study |
| title_full | Prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia: protocol for a cohort study |
| title_fullStr | Prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia: protocol for a cohort study |
| title_full_unstemmed | Prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia: protocol for a cohort study |
| title_short | Prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia: protocol for a cohort study |
| title_sort | prognostic factors for work disability in patients with chronic widespread pain and fibromyalgia protocol for a cohort study |
| url | https://bmjopen.bmj.com/content/11/12/e052919.full |
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