Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

Abstract Chimeric Antigen receptor T cell (CAR-T) treatments for solid cancers have been compromised by limited expansion and survival in the tumor microenvironment following interaction with antigen-expressing target cells. Using B7H3 as a model antigen with broad clinical applicability, we evaluat...

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Main Authors: Marta Barisa, Henrike P. Muller, Elisa Zappa, Rivani Shah, Juliane L. Buhl, Benjamin Draper, Courtney Himsworth, Chantelle Bowers, Sophie Munnings-Tomes, Marilena Nicolaidou, Sonia Morlando, Kathleen Birley, Clara Leboreiro-Babe, Alice Vitali, Laura Privitera, Kyle O’Sullivan, Ailsa Greppi, Magdalena Buschhaus, Mario Barrera Román, Sam de Blank, Femke van den Ham, Brenna R. van ‘t Veld, Gabrielle Ferry, Jonathan Fisher, Debarati Shome, Reza Nadafi, Israrul H. Ansari, Rogier Reijmers, Stefano Giuliani, Paul Sondel, Laura K. Donovan, Louis Chesler, Jan Molenaar, Jarno Drost, Anne C. Rios, Kerry Chester, Judith Wienke, John Anderson
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61427-4
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https://doi.org/10.1038/s41467-025-61427-4

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