Clinical Characteristics of De Novo Heart Failure and Acute Decompensated Chronic Heart Failure: Are They Distinctive Phenotypes That Contribute to Different Outcomes?
Heart failure is currently one of the leading causes of morbidity and mortality. Patients with heart failure often present with acute symptoms and may have a poor prognosis. Recent evidence shows differences in clinical characteristics and outcomes between de novo heart failure (DNHF) and acute deco...
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| Format: | Article |
| Language: | English |
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Radcliffe Medical Media
2021-02-01
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| Series: | Cardiac Failure Review |
| Online Access: | https://www.cfrjournal.com/articleindex/cfr.2020.20 |
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| _version_ | 1846122490644922368 |
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| author | Wilson Matthew Raffaello Joshua Henrina Ian Huang Michael Anthonius Lim Leonardo Paskah Suciadi Bambang Budi Siswanto Raymond Pranata |
| author_facet | Wilson Matthew Raffaello Joshua Henrina Ian Huang Michael Anthonius Lim Leonardo Paskah Suciadi Bambang Budi Siswanto Raymond Pranata |
| author_sort | Wilson Matthew Raffaello |
| collection | DOAJ |
| description | Heart failure is currently one of the leading causes of morbidity and mortality. Patients with heart failure often present with acute symptoms and may have a poor prognosis. Recent evidence shows differences in clinical characteristics and outcomes between de novo heart failure (DNHF) and acute decompensated chronic heart failure (ADCHF). Based on a better understanding of the distinct pathophysiology of these two conditions, new strategies may be considered to treat heart failure patients and improve outcomes. In this review, the authors elaborate distinctions regarding the clinical characteristics and outcomes of DNHF and ADCHF and their respective pathophysiology. Future clinical trials of therapies should address the potentially different phenotypes between DNHF and ADCHF if meaningful discoveries are to be made. |
| format | Article |
| id | doaj-art-b7b6864a9e374830bc7a2c93335deeb6 |
| institution | Kabale University |
| issn | 2057-7540 2057-7559 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Cardiac Failure Review |
| spelling | doaj-art-b7b6864a9e374830bc7a2c93335deeb62024-12-14T16:02:32ZengRadcliffe Medical MediaCardiac Failure Review2057-75402057-75592021-02-01710.15420/cfr.2020.20Clinical Characteristics of De Novo Heart Failure and Acute Decompensated Chronic Heart Failure: Are They Distinctive Phenotypes That Contribute to Different Outcomes?Wilson Matthew Raffaello0Joshua Henrina1Ian Huang2Michael Anthonius Lim3Leonardo Paskah Suciadi4Bambang Budi Siswanto5Raymond Pranata6Faculty of Medicine, Universitas Pelita Harapan, Tangerang, IndonesiaSiloam Heart Institute, Siloam Hospitals Kebon Jeruk, Jakarta, IndonesiaFaculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, IndonesiaFaculty of Medicine, Universitas Pelita Harapan, Tangerang, IndonesiaSiloam Heart Institute, Siloam Hospitals Kebon Jeruk, Jakarta, IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, IndonesiaFaculty of Medicine, Universitas Pelita Harapan, Tangerang, IndonesiaHeart failure is currently one of the leading causes of morbidity and mortality. Patients with heart failure often present with acute symptoms and may have a poor prognosis. Recent evidence shows differences in clinical characteristics and outcomes between de novo heart failure (DNHF) and acute decompensated chronic heart failure (ADCHF). Based on a better understanding of the distinct pathophysiology of these two conditions, new strategies may be considered to treat heart failure patients and improve outcomes. In this review, the authors elaborate distinctions regarding the clinical characteristics and outcomes of DNHF and ADCHF and their respective pathophysiology. Future clinical trials of therapies should address the potentially different phenotypes between DNHF and ADCHF if meaningful discoveries are to be made.https://www.cfrjournal.com/articleindex/cfr.2020.20 |
| spellingShingle | Wilson Matthew Raffaello Joshua Henrina Ian Huang Michael Anthonius Lim Leonardo Paskah Suciadi Bambang Budi Siswanto Raymond Pranata Clinical Characteristics of De Novo Heart Failure and Acute Decompensated Chronic Heart Failure: Are They Distinctive Phenotypes That Contribute to Different Outcomes? Cardiac Failure Review |
| title | Clinical Characteristics of De Novo Heart Failure and Acute Decompensated Chronic Heart Failure: Are They Distinctive Phenotypes That Contribute to Different Outcomes? |
| title_full | Clinical Characteristics of De Novo Heart Failure and Acute Decompensated Chronic Heart Failure: Are They Distinctive Phenotypes That Contribute to Different Outcomes? |
| title_fullStr | Clinical Characteristics of De Novo Heart Failure and Acute Decompensated Chronic Heart Failure: Are They Distinctive Phenotypes That Contribute to Different Outcomes? |
| title_full_unstemmed | Clinical Characteristics of De Novo Heart Failure and Acute Decompensated Chronic Heart Failure: Are They Distinctive Phenotypes That Contribute to Different Outcomes? |
| title_short | Clinical Characteristics of De Novo Heart Failure and Acute Decompensated Chronic Heart Failure: Are They Distinctive Phenotypes That Contribute to Different Outcomes? |
| title_sort | clinical characteristics of de novo heart failure and acute decompensated chronic heart failure are they distinctive phenotypes that contribute to different outcomes |
| url | https://www.cfrjournal.com/articleindex/cfr.2020.20 |
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