Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency
Background Treatment of chronic cough remains a challenge. We hypothesised that inhaled alkaline hypertonic divalent salts (alkaline HDS) might provide relief for refractory chronic cough by laryngeal and tracheal hydration. Methods We conducted an exploratory, single-blinded, nasal saline-controlle...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-10-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/5/00241-2024.full |
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| author | Hisham Abubakar-Waziri David A. Edwards Deen Bhandu Bhatta James H. Hull Matthew Rudd Peter Small Kian Fan Chung |
| author_facet | Hisham Abubakar-Waziri David A. Edwards Deen Bhandu Bhatta James H. Hull Matthew Rudd Peter Small Kian Fan Chung |
| author_sort | Hisham Abubakar-Waziri |
| collection | DOAJ |
| description | Background
Treatment of chronic cough remains a challenge. We hypothesised that inhaled alkaline hypertonic divalent salts (alkaline HDS) might provide relief for refractory chronic cough by laryngeal and tracheal hydration.
Methods
We conducted an exploratory, single-blinded, nasal saline-controlled study in 12 refractory chronic cough patients to examine cough suppression efficacy of an alkaline HDS composition (SC001) at pH 8 or pH 9 administered by nasal inhalation. As control, we used nasal saline with the same hand-held pump spray aerosol device. Each subject was monitored continuously using a digital cough monitor watch for 1 week of baseline, 1 week of control treatment and 1 week of active treatment.
Results
Baseline daily cough rates ranged from 4 to 34 coughs·h−1 with mean visual analogue score 65±17 pre- and post-baseline testing. Control-adjusted efficacy of cough rate reduction ranged from 15% (p=0.015) (from Day 1) to 23% (p=0.002) (from Day 3). Control-adjusted efficacy was highest with SC001 pH 9 (n=5), ranging from 25% (p=0.03) (from Day 1) to 35% (p=0.02) (from Day 3), and lowest for SC001 pH 8 (n=7), ranging from 9% (p=0.08) (from Day 1) to 16% (p=0.02) (from Day 3). Hourly cough counts and visual analogue score correlated for baseline (r=0.254, p=0.02) and control (r=0.299, p=0.007) monitoring weeks. Treatment improved this correlation (r=0.434, p=0.00006). No adverse events were reported.
Conclusions
Alkaline (pH 9) HDS aerosol is a promising treatment for refractory chronic cough and should be further evaluated. |
| format | Article |
| id | doaj-art-b7b50f86db8c4494b9289d2dc6fb5cf7 |
| institution | Kabale University |
| issn | 2312-0541 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-b7b50f86db8c4494b9289d2dc6fb5cf72024-11-11T16:33:07ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-10-0110510.1183/23120541.00241-202400241-2024Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequencyHisham Abubakar-Waziri0David A. Edwards1Deen Bhandu Bhatta2James H. Hull3Matthew Rudd4Peter Small5Kian Fan Chung6 National Heart and Lung Institute, Imperial College London, and Royal Brompton and Harefield Hospital, London, UK Center for Nanomedicine, Johns Hopkins University Medical School, Baltimore, MD, USA Sensory Cloud Inc., Boston, MA, USA National Heart and Lung Institute, Imperial College London, and Royal Brompton and Harefield Hospital, London, UK Hyfe Inc., Wilmington, DE, USA Hyfe Inc., Wilmington, DE, USA National Heart and Lung Institute, Imperial College London, and Royal Brompton and Harefield Hospital, London, UK Background Treatment of chronic cough remains a challenge. We hypothesised that inhaled alkaline hypertonic divalent salts (alkaline HDS) might provide relief for refractory chronic cough by laryngeal and tracheal hydration. Methods We conducted an exploratory, single-blinded, nasal saline-controlled study in 12 refractory chronic cough patients to examine cough suppression efficacy of an alkaline HDS composition (SC001) at pH 8 or pH 9 administered by nasal inhalation. As control, we used nasal saline with the same hand-held pump spray aerosol device. Each subject was monitored continuously using a digital cough monitor watch for 1 week of baseline, 1 week of control treatment and 1 week of active treatment. Results Baseline daily cough rates ranged from 4 to 34 coughs·h−1 with mean visual analogue score 65±17 pre- and post-baseline testing. Control-adjusted efficacy of cough rate reduction ranged from 15% (p=0.015) (from Day 1) to 23% (p=0.002) (from Day 3). Control-adjusted efficacy was highest with SC001 pH 9 (n=5), ranging from 25% (p=0.03) (from Day 1) to 35% (p=0.02) (from Day 3), and lowest for SC001 pH 8 (n=7), ranging from 9% (p=0.08) (from Day 1) to 16% (p=0.02) (from Day 3). Hourly cough counts and visual analogue score correlated for baseline (r=0.254, p=0.02) and control (r=0.299, p=0.007) monitoring weeks. Treatment improved this correlation (r=0.434, p=0.00006). No adverse events were reported. Conclusions Alkaline (pH 9) HDS aerosol is a promising treatment for refractory chronic cough and should be further evaluated.http://openres.ersjournals.com/content/10/5/00241-2024.full |
| spellingShingle | Hisham Abubakar-Waziri David A. Edwards Deen Bhandu Bhatta James H. Hull Matthew Rudd Peter Small Kian Fan Chung Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency ERJ Open Research |
| title | Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency |
| title_full | Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency |
| title_fullStr | Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency |
| title_full_unstemmed | Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency |
| title_short | Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency |
| title_sort | inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency |
| url | http://openres.ersjournals.com/content/10/5/00241-2024.full |
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