Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insights
Abstract Thromboembolic disorders, including deep vein thrombosis (DVT) and pulmonary embolism (PE), are major global health concerns, causing significant morbidity and mortality. Early diagnosis is crucial for effective treatment and improved patient outcomes. Recent research has identified Apelin-...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | International Journal of Emergency Medicine |
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| Online Access: | https://doi.org/10.1186/s12245-024-00774-3 |
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| author | Mehdi Karimi Niyousha Shirsalimi Eshagh Sedighi |
| author_facet | Mehdi Karimi Niyousha Shirsalimi Eshagh Sedighi |
| author_sort | Mehdi Karimi |
| collection | DOAJ |
| description | Abstract Thromboembolic disorders, including deep vein thrombosis (DVT) and pulmonary embolism (PE), are major global health concerns, causing significant morbidity and mortality. Early diagnosis is crucial for effective treatment and improved patient outcomes. Recent research has identified Apelin-13, a bioactive peptide in the apelin family, as a promising diagnostic biomarker for Thromboembolic disorders. Apelin-13 supports vascular health by regulating protease balance through plasminogen activator inhibitors and modulating endothelial cell function. Additionally, it plays a vital role in coagulation, with elevated levels associated with an increased risk of clot formation, suggesting its utility in predicting thrombosis risk, particularly in preoperative evaluations. Findings indicate that the Apelin-13 pathway shows significant promise as a biomarker for Thromboembolic disorders, underscoring its potential therapeutic applications and the need for further investigation. This review synthesizes current literature on thromboembolic disorders and associated laboratory biomarkers, with a particular focus on Apelin-13. It examines Apelin-13’s role in disease mechanisms, its physiological functions, and its potential as a diagnostic biomarker in thromboembolic conditions. |
| format | Article |
| id | doaj-art-b79c7fbbb30b4efdbdf6bb82f554ddc5 |
| institution | Kabale University |
| issn | 1865-1380 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Emergency Medicine |
| spelling | doaj-art-b79c7fbbb30b4efdbdf6bb82f554ddc52024-12-22T12:12:43ZengBMCInternational Journal of Emergency Medicine1865-13802024-12-0117111510.1186/s12245-024-00774-3Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insightsMehdi Karimi0Niyousha Shirsalimi1Eshagh Sedighi2Faculty of Medicine, Bogomolets National Medical University (NMU)Faculty of Medicine, Bogomolets National Medical University (NMU)Faculty of Medicine, Hamadan University of Medical Science (UMSHA)Abstract Thromboembolic disorders, including deep vein thrombosis (DVT) and pulmonary embolism (PE), are major global health concerns, causing significant morbidity and mortality. Early diagnosis is crucial for effective treatment and improved patient outcomes. Recent research has identified Apelin-13, a bioactive peptide in the apelin family, as a promising diagnostic biomarker for Thromboembolic disorders. Apelin-13 supports vascular health by regulating protease balance through plasminogen activator inhibitors and modulating endothelial cell function. Additionally, it plays a vital role in coagulation, with elevated levels associated with an increased risk of clot formation, suggesting its utility in predicting thrombosis risk, particularly in preoperative evaluations. Findings indicate that the Apelin-13 pathway shows significant promise as a biomarker for Thromboembolic disorders, underscoring its potential therapeutic applications and the need for further investigation. This review synthesizes current literature on thromboembolic disorders and associated laboratory biomarkers, with a particular focus on Apelin-13. It examines Apelin-13’s role in disease mechanisms, its physiological functions, and its potential as a diagnostic biomarker in thromboembolic conditions.https://doi.org/10.1186/s12245-024-00774-3Apelin-13BiomarkerThromboembolicThrombosisEmbolismCardiovascular |
| spellingShingle | Mehdi Karimi Niyousha Shirsalimi Eshagh Sedighi Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insights International Journal of Emergency Medicine Apelin-13 Biomarker Thromboembolic Thrombosis Embolism Cardiovascular |
| title | Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insights |
| title_full | Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insights |
| title_fullStr | Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insights |
| title_full_unstemmed | Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insights |
| title_short | Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insights |
| title_sort | apelin 13 as a novel diagnostic laboratory biomarker in thromboembolic disorders a review of literature with prospective insights |
| topic | Apelin-13 Biomarker Thromboembolic Thrombosis Embolism Cardiovascular |
| url | https://doi.org/10.1186/s12245-024-00774-3 |
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