Nernst–Planck–Gaussian finite element modelling of Ca2+ electrodiffusion in amphibian striated muscle transverse tubule–sarcoplasmic reticular triadic junctional domains

Nernst–Planck–Gaussian finite element modelling of Ca2+ electrodiffusion in amphibian striated muscle transverse tubule–sarcoplasmic reticular triadic junctional domains

IntroductionIntracellular Ca2+ signalling regulates membrane permeabilities, enzyme activity, and gene transcription amongst other functions. Large transmembrane Ca2+ electrochemical gradients and low diffusibility between cell compartments potentially generate short-lived, localised, high-[Ca2+] mi...

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Bibliographic Details
Main Authors: Marco D. Rodríguez, Joshua A. Morris, Oliver J. Bardsley, Hugh R. Matthews, Christopher L.-H. Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Physiology
Subjects:
skeletal muscle
excitation–contraction coupling
triad junction
calcium microdomains
Nernst–Planck equation
electrodiffusion
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1468333/full
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