Preliminary study on the diagnostic value of urine cell glucose metabolism detection for male urothelial carcinoma
This study assessed the potential of urine abnormal glycolytic metabolism detection versus urine cytology in diagnosing male urothelial carcinoma, using pathological results as the gold standard. Urine samples were collected from suspected urothelial carcinoma male patients at Zhejiang Cancer Hos...
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MRE Press
2024-12-01
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| Series: | Journal of Men's Health |
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| Online Access: | https://oss.jomh.org/files/article/20241230-453/pdf/JOMH2024050502.pdf |
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| author | Yaoyao Wu Angchao Ye Zhenguo Bu Shaoxing Zhu He Wang Yipeng Xu |
| author_facet | Yaoyao Wu Angchao Ye Zhenguo Bu Shaoxing Zhu He Wang Yipeng Xu |
| author_sort | Yaoyao Wu |
| collection | DOAJ |
| description | This study assessed the potential of urine abnormal glycolytic metabolism
detection versus urine cytology in diagnosing male urothelial carcinoma, using
pathological results as the gold standard. Urine samples were collected from
suspected urothelial carcinoma male patients at Zhejiang Cancer Hospital from
September 2021 to February 2024. Both urine cell glycometabolism detection and
urine cytology examination were performed on the same samples, with clinical data
including tumor classification and grading gathered for statistical analysis. A
total of 105 male patients were enrolled, with 83 (79.05%) diagnosed with
urothelial carcinoma. Stratified analysis based on urine glycometabolism
detection (high risk, low risk, no abnormalities) showed the sensitivity,
specificity and Area Under Curve (AUC) values of “Glucose metabolism 1” (high
risk) as 74.70%, 59.09% and 0.6689 (p = 0.0151), and “Glucose
metabolism 2” (high/low risk) as 82.56%, 59.09% and 0.7082 (p =
0.0027). Urine cytology results showed the sensitivity, specificity, and AUC
values of “Urine Exfoliative 1” (malignant tumor cells found) as 22.89%,
90.91% and 0.5690 (p = 0.3211), “Urine Exfoliative 2” (finding or
suspecting malignant tumor cells) as 42.17%, 90.91% and 0.6654 (p =
0.0174), and “Urine Exfoliative 3” (finding/suspecting/not excluding malignant
tumor cells) as 60.24%, 72.73% and 0.6648 (p = 0.0178). The combined
diagnosis of “Glucose metabolism 2” and “Urine Exfoliative 4” (no tumor cells
found) improved diagnostic efficiency, with sensitivity 62.65%, specificity
95.45% and AUC = 0.7905 (p < 0.0001). “Glucose metabolism 2” had a
sensitivity of 86.21% for low-grade urothelial carcinoma, while “Urine
Exfoliative 4” had a sensitivity of 58.62%. Compared to urine cytology, urine
cell glycometabolism detection improved sensitivity for diagnosing urothelial
carcinoma but had lower specificity. Combined diagnosis enhanced sensitivity and
specificity, and glycometabolism detection showed superior sensitivity for
low-grade urothelial carcinoma, serving as an efficient non-invasive diagnostic
tool. |
| format | Article |
| id | doaj-art-b7863a5d61dd4b6ba8ba2835db0a535b |
| institution | Kabale University |
| issn | 1875-6867 1875-6859 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MRE Press |
| record_format | Article |
| series | Journal of Men's Health |
| spelling | doaj-art-b7863a5d61dd4b6ba8ba2835db0a535b2025-01-03T08:41:59ZengMRE PressJournal of Men's Health1875-68671875-68592024-12-01201211812910.22514/jomh.2024.207S1875-6867(24)00315-4Preliminary study on the diagnostic value of urine cell glucose metabolism detection for male urothelial carcinomaYaoyao Wu0Angchao Ye1Zhenguo Bu2Shaoxing Zhu3He Wang4Yipeng Xu5The Second School of Clinical Medical, Zhejiang Chinese Medical University, 310059 Hangzhou, Zhejiang, ChinaDepartment of Neurology, Integrated Traditional Chinese and Western Medicine Hospital of Linping District, 310005 Hangzhou, Zhejiang, ChinaDepartment of Radiation Physics, Zhejiang Cancer Hospital, 310022 Hangzhou, Zhejiang, ChinaDepartment of Urology, Fujian Medical University Union Hospital, 350001 Fuzhou, Fujian, ChinaThe Second School of Clinical Medical, Zhejiang Chinese Medical University, 310059 Hangzhou, Zhejiang, ChinaDepartment of Urology, Zhejiang Cancer Hospital, 310022 Hangzhou, Zhejiang, ChinaThis study assessed the potential of urine abnormal glycolytic metabolism detection versus urine cytology in diagnosing male urothelial carcinoma, using pathological results as the gold standard. Urine samples were collected from suspected urothelial carcinoma male patients at Zhejiang Cancer Hospital from September 2021 to February 2024. Both urine cell glycometabolism detection and urine cytology examination were performed on the same samples, with clinical data including tumor classification and grading gathered for statistical analysis. A total of 105 male patients were enrolled, with 83 (79.05%) diagnosed with urothelial carcinoma. Stratified analysis based on urine glycometabolism detection (high risk, low risk, no abnormalities) showed the sensitivity, specificity and Area Under Curve (AUC) values of “Glucose metabolism 1” (high risk) as 74.70%, 59.09% and 0.6689 (p = 0.0151), and “Glucose metabolism 2” (high/low risk) as 82.56%, 59.09% and 0.7082 (p = 0.0027). Urine cytology results showed the sensitivity, specificity, and AUC values of “Urine Exfoliative 1” (malignant tumor cells found) as 22.89%, 90.91% and 0.5690 (p = 0.3211), “Urine Exfoliative 2” (finding or suspecting malignant tumor cells) as 42.17%, 90.91% and 0.6654 (p = 0.0174), and “Urine Exfoliative 3” (finding/suspecting/not excluding malignant tumor cells) as 60.24%, 72.73% and 0.6648 (p = 0.0178). The combined diagnosis of “Glucose metabolism 2” and “Urine Exfoliative 4” (no tumor cells found) improved diagnostic efficiency, with sensitivity 62.65%, specificity 95.45% and AUC = 0.7905 (p < 0.0001). “Glucose metabolism 2” had a sensitivity of 86.21% for low-grade urothelial carcinoma, while “Urine Exfoliative 4” had a sensitivity of 58.62%. Compared to urine cytology, urine cell glycometabolism detection improved sensitivity for diagnosing urothelial carcinoma but had lower specificity. Combined diagnosis enhanced sensitivity and specificity, and glycometabolism detection showed superior sensitivity for low-grade urothelial carcinoma, serving as an efficient non-invasive diagnostic tool.https://oss.jomh.org/files/article/20241230-453/pdf/JOMH2024050502.pdfurine cell glycometabolism detectionurine cytology examinationurothelial carcinomasensitivityspecificity |
| spellingShingle | Yaoyao Wu Angchao Ye Zhenguo Bu Shaoxing Zhu He Wang Yipeng Xu Preliminary study on the diagnostic value of urine cell glucose metabolism detection for male urothelial carcinoma Journal of Men's Health urine cell glycometabolism detection urine cytology examination urothelial carcinoma sensitivity specificity |
| title | Preliminary study on the diagnostic value of urine cell glucose metabolism detection for male urothelial carcinoma |
| title_full | Preliminary study on the diagnostic value of urine cell glucose metabolism detection for male urothelial carcinoma |
| title_fullStr | Preliminary study on the diagnostic value of urine cell glucose metabolism detection for male urothelial carcinoma |
| title_full_unstemmed | Preliminary study on the diagnostic value of urine cell glucose metabolism detection for male urothelial carcinoma |
| title_short | Preliminary study on the diagnostic value of urine cell glucose metabolism detection for male urothelial carcinoma |
| title_sort | preliminary study on the diagnostic value of urine cell glucose metabolism detection for male urothelial carcinoma |
| topic | urine cell glycometabolism detection urine cytology examination urothelial carcinoma sensitivity specificity |
| url | https://oss.jomh.org/files/article/20241230-453/pdf/JOMH2024050502.pdf |
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