Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice
Aging is associated with cognitive decline, and currently, there are no approved medications that can prevent these impairments. Recently, cannabinoids derived from Cannabis sativa have emerged as promising therapeutic compounds with neuroprotective, anti-inflammatory, and cognitive-enhancing proper...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1567650/full |
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| author | Behroo Mirza Agha Merrin Monteith Jarem Earl Keona Ganske Tina Kaloa Kelan J. McDonald Abigail G. Nixon Maleeha Panjwani Danika Robinson Valeria Rusnak Majid H. Mohajerani Igor Kovalchuk Robert J. Sutherland Nancy S. Hong Robert J. McDonald |
| author_facet | Behroo Mirza Agha Merrin Monteith Jarem Earl Keona Ganske Tina Kaloa Kelan J. McDonald Abigail G. Nixon Maleeha Panjwani Danika Robinson Valeria Rusnak Majid H. Mohajerani Igor Kovalchuk Robert J. Sutherland Nancy S. Hong Robert J. McDonald |
| author_sort | Behroo Mirza Agha |
| collection | DOAJ |
| description | Aging is associated with cognitive decline, and currently, there are no approved medications that can prevent these impairments. Recently, cannabinoids derived from Cannabis sativa have emerged as promising therapeutic compounds with neuroprotective, anti-inflammatory, and cognitive-enhancing properties. Despite their benefits, further research is needed to fully understand their efficacy across various conditions. This study investigates the effects of cannabidiol (CBD) on memory impairment and brain inflammation in aging mice. Fourteen-month-old C57 mice were administered CBD orally for 7 months and subsequently evaluated between 19 and 21 months of age using behavioral tasks that are sensitive to dysfunction of the perirhinal cortex, hippocampus, amygdala, and various brain regions that are crucial for motor control and coordination. The findings of this study indicate that CBD reduces inflammatory response in the brain and improves cognitive decline associated with aging. |
| format | Article |
| id | doaj-art-b742f3d1a24b486bbc9f71cd76bb0f5e |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-b742f3d1a24b486bbc9f71cd76bb0f5e2025-08-20T03:48:47ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-05-011710.3389/fnagi.2025.15676501567650Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 miceBehroo Mirza Agha0Merrin Monteith1Jarem Earl2Keona Ganske3Tina Kaloa4Kelan J. McDonald5Abigail G. Nixon6Maleeha Panjwani7Danika Robinson8Valeria Rusnak9Majid H. Mohajerani10Igor Kovalchuk11Robert J. Sutherland12Nancy S. Hong13Robert J. McDonald14Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaDouglas Research Centre, Department of Psychiatry, McGill University, Montréal, QC, CanadaDepartment of Biological Sciences, University of Lethbridge, Lethbridge, AB, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB, CanadaAging is associated with cognitive decline, and currently, there are no approved medications that can prevent these impairments. Recently, cannabinoids derived from Cannabis sativa have emerged as promising therapeutic compounds with neuroprotective, anti-inflammatory, and cognitive-enhancing properties. Despite their benefits, further research is needed to fully understand their efficacy across various conditions. This study investigates the effects of cannabidiol (CBD) on memory impairment and brain inflammation in aging mice. Fourteen-month-old C57 mice were administered CBD orally for 7 months and subsequently evaluated between 19 and 21 months of age using behavioral tasks that are sensitive to dysfunction of the perirhinal cortex, hippocampus, amygdala, and various brain regions that are crucial for motor control and coordination. The findings of this study indicate that CBD reduces inflammatory response in the brain and improves cognitive decline associated with aging.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1567650/fullagingage-related cognitive declinecannabidiol (CBD)learning and memoryhippocampusprefrontal cortex |
| spellingShingle | Behroo Mirza Agha Merrin Monteith Jarem Earl Keona Ganske Tina Kaloa Kelan J. McDonald Abigail G. Nixon Maleeha Panjwani Danika Robinson Valeria Rusnak Majid H. Mohajerani Igor Kovalchuk Robert J. Sutherland Nancy S. Hong Robert J. McDonald Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice Frontiers in Aging Neuroscience aging age-related cognitive decline cannabidiol (CBD) learning and memory hippocampus prefrontal cortex |
| title | Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice |
| title_full | Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice |
| title_fullStr | Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice |
| title_full_unstemmed | Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice |
| title_short | Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice |
| title_sort | effects of cannabidiol cbd treatment on age related cognitive decline in c57 mice |
| topic | aging age-related cognitive decline cannabidiol (CBD) learning and memory hippocampus prefrontal cortex |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1567650/full |
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