To Compare and Evaluate the Efficacy of 1% Alendronate Gel and 10% Doxycycline Gel as an Adjunct to SRP in Patients with Chronic Periodontitis: A Randomized Controlled Clinical Trial
Background: Modern medicine has advanced drug delivery strategies for improved treatment outcomes with minimal systemic side effects. Local drug delivery is a promising approach, targeting therapeutic agents to specific tissues or organs, optimizing efficacy by concentrating medications at the site...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_520_24 |
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| _version_ | 1841544155473379328 |
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| author | Laloo Phassang Radhika Kapoor Prashant Tyagi Amit Wadhawan |
| author_facet | Laloo Phassang Radhika Kapoor Prashant Tyagi Amit Wadhawan |
| author_sort | Laloo Phassang |
| collection | DOAJ |
| description | Background:
Modern medicine has advanced drug delivery strategies for improved treatment outcomes with minimal systemic side effects. Local drug delivery is a promising approach, targeting therapeutic agents to specific tissues or organs, optimizing efficacy by concentrating medications at the site of action. This method offers advantages over systemic delivery, such as reduced dosage and frequency, minimized systemic toxicity, and the avoidance of gastrointestinal issues and first-pass metabolism. Researchers are continually seeking ways to enhance the safety and effectiveness of local drug delivery systems through new materials.
Aim and Objectives:
To evaluate and compare the clinical efficacy of 1% alendronate gel and 10% doxycycline gel when used as an adjunct to scaling and root planning in the treatment of patients with chronic periodontitis.
Methodology:
The study was conducted in Shree Bankey Bihari Dental College & Research Centre in Ghaziabad. In this randomized controlled trial, the impact of the local drug delivery agents on the pocket depths of 45 patients was assessed over six months. Changes in gingival index (GI), plaque index (PI), probing pocket depth (PPD), and relative attachment level (RAL) were measured across three groups: a control group (Group C) and two experimental groups (Group A and B). Acrylic stents were used to evaluate probing depth and attachment loss post-surgery, determining the relative attachment level.
Results:
At 3 and 6 months post-treatment, Group A showed superior results in gingival index, plaque index, probing depth, and relative attachment level compared to Group B. Both Groups A and B demonstrated significant improvements over Group C. A statistically significant difference was observed when comparing Groups A and B separately.
Conclusion:
The study found that both Group A and Group B showed better outcomes than Group C at the 3- and 6-month marks. A statistically significant difference was observed between Group A and Group B, with Group A (SRP + 1% alendronate gel) outperforming Group B (SRP + 10% doxycycline gel) in improving the periodontal index, sulcular depth, and relative attachment level. |
| format | Article |
| id | doaj-art-b72c803a13fd48ee88be72cb8b6cd49d |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-b72c803a13fd48ee88be72cb8b6cd49d2025-01-12T14:07:08ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3153S315510.4103/jpbs.jpbs_520_24To Compare and Evaluate the Efficacy of 1% Alendronate Gel and 10% Doxycycline Gel as an Adjunct to SRP in Patients with Chronic Periodontitis: A Randomized Controlled Clinical TrialLaloo PhassangRadhika KapoorPrashant TyagiAmit WadhawanBackground: Modern medicine has advanced drug delivery strategies for improved treatment outcomes with minimal systemic side effects. Local drug delivery is a promising approach, targeting therapeutic agents to specific tissues or organs, optimizing efficacy by concentrating medications at the site of action. This method offers advantages over systemic delivery, such as reduced dosage and frequency, minimized systemic toxicity, and the avoidance of gastrointestinal issues and first-pass metabolism. Researchers are continually seeking ways to enhance the safety and effectiveness of local drug delivery systems through new materials. Aim and Objectives: To evaluate and compare the clinical efficacy of 1% alendronate gel and 10% doxycycline gel when used as an adjunct to scaling and root planning in the treatment of patients with chronic periodontitis. Methodology: The study was conducted in Shree Bankey Bihari Dental College & Research Centre in Ghaziabad. In this randomized controlled trial, the impact of the local drug delivery agents on the pocket depths of 45 patients was assessed over six months. Changes in gingival index (GI), plaque index (PI), probing pocket depth (PPD), and relative attachment level (RAL) were measured across three groups: a control group (Group C) and two experimental groups (Group A and B). Acrylic stents were used to evaluate probing depth and attachment loss post-surgery, determining the relative attachment level. Results: At 3 and 6 months post-treatment, Group A showed superior results in gingival index, plaque index, probing depth, and relative attachment level compared to Group B. Both Groups A and B demonstrated significant improvements over Group C. A statistically significant difference was observed when comparing Groups A and B separately. Conclusion: The study found that both Group A and Group B showed better outcomes than Group C at the 3- and 6-month marks. A statistically significant difference was observed between Group A and Group B, with Group A (SRP + 1% alendronate gel) outperforming Group B (SRP + 10% doxycycline gel) in improving the periodontal index, sulcular depth, and relative attachment level.https://journals.lww.com/10.4103/jpbs.jpbs_520_241% alendronate gel10% doxycycline gelchronic periodontitissrp |
| spellingShingle | Laloo Phassang Radhika Kapoor Prashant Tyagi Amit Wadhawan To Compare and Evaluate the Efficacy of 1% Alendronate Gel and 10% Doxycycline Gel as an Adjunct to SRP in Patients with Chronic Periodontitis: A Randomized Controlled Clinical Trial Journal of Pharmacy and Bioallied Sciences 1% alendronate gel 10% doxycycline gel chronic periodontitis srp |
| title | To Compare and Evaluate the Efficacy of 1% Alendronate Gel and 10% Doxycycline Gel as an Adjunct to SRP in Patients with Chronic Periodontitis: A Randomized Controlled Clinical Trial |
| title_full | To Compare and Evaluate the Efficacy of 1% Alendronate Gel and 10% Doxycycline Gel as an Adjunct to SRP in Patients with Chronic Periodontitis: A Randomized Controlled Clinical Trial |
| title_fullStr | To Compare and Evaluate the Efficacy of 1% Alendronate Gel and 10% Doxycycline Gel as an Adjunct to SRP in Patients with Chronic Periodontitis: A Randomized Controlled Clinical Trial |
| title_full_unstemmed | To Compare and Evaluate the Efficacy of 1% Alendronate Gel and 10% Doxycycline Gel as an Adjunct to SRP in Patients with Chronic Periodontitis: A Randomized Controlled Clinical Trial |
| title_short | To Compare and Evaluate the Efficacy of 1% Alendronate Gel and 10% Doxycycline Gel as an Adjunct to SRP in Patients with Chronic Periodontitis: A Randomized Controlled Clinical Trial |
| title_sort | to compare and evaluate the efficacy of 1 alendronate gel and 10 doxycycline gel as an adjunct to srp in patients with chronic periodontitis a randomized controlled clinical trial |
| topic | 1% alendronate gel 10% doxycycline gel chronic periodontitis srp |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_520_24 |
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