Gut-mammary pathway: Breast milk microbiota as a mediator of maternal gut microbiota transfer to the infant gut
This observational study investigated the transfer of maternal gut microbiota to the infant gut through breast milk and its implications for infant gut health. Fecal and breast milk samples were collected from 23 healthy mother-infant pairs, with 11 breast milk samples testing positive for microbial...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006236 |
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| author | Lulu Meng Haishan Xie Zhe Li Kian Deng Tye Ge Fan Ting Huang Hao Yan Xiaomei Tang Huijuan Luo Xiaomin Xiao |
| author_facet | Lulu Meng Haishan Xie Zhe Li Kian Deng Tye Ge Fan Ting Huang Hao Yan Xiaomei Tang Huijuan Luo Xiaomin Xiao |
| author_sort | Lulu Meng |
| collection | DOAJ |
| description | This observational study investigated the transfer of maternal gut microbiota to the infant gut through breast milk and its implications for infant gut health. Fecal and breast milk samples were collected from 23 healthy mother-infant pairs, with 11 breast milk samples testing positive for microbial presence. Microbial source tracking revealed that 22.89 % of breast milk microbiota originated from the maternal gut, and 25.64 % of the infant gut microbiota was derived from breast milk. Shared OTUs between the paired maternal gut, breast milk, and infant gut had a median of 109 (range: 61–148). Genera such as Bifidobacterium, Escherichia-Shigella, and Bacteroides were common across the three sites. Comparisons with the sterile milk group (n = 12) indicated a potential role for breast milk microbiota in maternal-infant microbiota transmission. This study highlights breast milk as a significant medium for microbiota transfer and provides a theoretical basis for promoting infant gut health. |
| format | Article |
| id | doaj-art-b728d426419d4db69a2a28a4bbdeb1f0 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-b728d426419d4db69a2a28a4bbdeb1f02025-01-12T05:24:42ZengElsevierJournal of Functional Foods1756-46462025-01-01124106620Gut-mammary pathway: Breast milk microbiota as a mediator of maternal gut microbiota transfer to the infant gutLulu Meng0Haishan Xie1Zhe Li2Kian Deng Tye3Ge Fan4Ting Huang5Hao Yan6Xiaomei Tang7Huijuan Luo8Xiaomin Xiao9Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, China; Corresponding author.This observational study investigated the transfer of maternal gut microbiota to the infant gut through breast milk and its implications for infant gut health. Fecal and breast milk samples were collected from 23 healthy mother-infant pairs, with 11 breast milk samples testing positive for microbial presence. Microbial source tracking revealed that 22.89 % of breast milk microbiota originated from the maternal gut, and 25.64 % of the infant gut microbiota was derived from breast milk. Shared OTUs between the paired maternal gut, breast milk, and infant gut had a median of 109 (range: 61–148). Genera such as Bifidobacterium, Escherichia-Shigella, and Bacteroides were common across the three sites. Comparisons with the sterile milk group (n = 12) indicated a potential role for breast milk microbiota in maternal-infant microbiota transmission. This study highlights breast milk as a significant medium for microbiota transfer and provides a theoretical basis for promoting infant gut health.http://www.sciencedirect.com/science/article/pii/S1756464624006236Gut microbiotaMilk microbiotaBreast milkBreastfeedingMicrobial transferInfant |
| spellingShingle | Lulu Meng Haishan Xie Zhe Li Kian Deng Tye Ge Fan Ting Huang Hao Yan Xiaomei Tang Huijuan Luo Xiaomin Xiao Gut-mammary pathway: Breast milk microbiota as a mediator of maternal gut microbiota transfer to the infant gut Journal of Functional Foods Gut microbiota Milk microbiota Breast milk Breastfeeding Microbial transfer Infant |
| title | Gut-mammary pathway: Breast milk microbiota as a mediator of maternal gut microbiota transfer to the infant gut |
| title_full | Gut-mammary pathway: Breast milk microbiota as a mediator of maternal gut microbiota transfer to the infant gut |
| title_fullStr | Gut-mammary pathway: Breast milk microbiota as a mediator of maternal gut microbiota transfer to the infant gut |
| title_full_unstemmed | Gut-mammary pathway: Breast milk microbiota as a mediator of maternal gut microbiota transfer to the infant gut |
| title_short | Gut-mammary pathway: Breast milk microbiota as a mediator of maternal gut microbiota transfer to the infant gut |
| title_sort | gut mammary pathway breast milk microbiota as a mediator of maternal gut microbiota transfer to the infant gut |
| topic | Gut microbiota Milk microbiota Breast milk Breastfeeding Microbial transfer Infant |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006236 |
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