Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo.
<h4>Background</h4>Few studies have assessed the impact of first-trimester malaria infection during pregnancy. We estimated this impact on adverse maternal and pregnancy outcomes.<h4>Methods</h4>In a convenience sample of women from the ASPIRIN (Aspirin Supplementation for Pr...
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Public Library of Science (PLoS)
2024-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0310339 |
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| author | Sequoia I Leuba Daniel Westreich Carl L Bose Andrew F Olshan Steve M Taylor Antoinette Tshefu Adrien Lokangaka Waldemar A Carlo Elwyn Chomba Musaku Mwenechanya Edward A Liechty Sherri L Bucher Osayame A Ekhaguere Fabian Esamai Paul Nyongesa Saleem Jessani Sarah Saleem Robert L Goldenberg Janet L Moore Tracy L Nolen Jennifer Hemingway-Foday Elizabeth M McClure Marion Koso-Thomas Richard J Derman Matthew Hoffman Steven R Meshnick Melissa Bauserman |
| author_facet | Sequoia I Leuba Daniel Westreich Carl L Bose Andrew F Olshan Steve M Taylor Antoinette Tshefu Adrien Lokangaka Waldemar A Carlo Elwyn Chomba Musaku Mwenechanya Edward A Liechty Sherri L Bucher Osayame A Ekhaguere Fabian Esamai Paul Nyongesa Saleem Jessani Sarah Saleem Robert L Goldenberg Janet L Moore Tracy L Nolen Jennifer Hemingway-Foday Elizabeth M McClure Marion Koso-Thomas Richard J Derman Matthew Hoffman Steven R Meshnick Melissa Bauserman |
| author_sort | Sequoia I Leuba |
| collection | DOAJ |
| description | <h4>Background</h4>Few studies have assessed the impact of first-trimester malaria infection during pregnancy. We estimated this impact on adverse maternal and pregnancy outcomes.<h4>Methods</h4>In a convenience sample of women from the ASPIRIN (Aspirin Supplementation for Pregnancy Indicated risk Reduction In Nulliparas) trial in Kenya, Zambia, and the Democratic Republic of the Congo, we tested for first-trimester Plasmodium falciparum infection using quantitative polymerase chain reaction. We estimated site-specific effects on pregnancy outcomes using parametric g-computation.<h4>Results</h4>Compared to uninfected women, we observed the adjusted site-specific prevalence differences (PDs) among women with first-trimester malaria of the following pregnancy outcomes: preterm birth among Congolese (aPD = 0.06 [99% CI: -0.04, 0.16]), Kenyan (0.03 [-0.04, 0.09]), and Zambian (0.00 [-0.10, 0.20]) women; low birth weight among Congolese (0.07 [-0.03, 0.16]), Kenyan (0.01 [-0.04, 0.06]) and Zambian (-0.04 [-0.13, 0.16]) women; spontaneous abortion among Congolese (0.00 [-0.05, 0.04]), Kenyan (0.00 [-0.04, 0.04]), and Zambian (0.02 [-0.07, 0.24]) women, and anemia later in pregnancy among Congolese (0.04 [-0.09, 0.16]), Kenyan (0.05 [-0.06, 0.17]), and Zambian (0.07 [-0.12, 0.36]) women. The pooled PD for anemia later in pregnancy (26-30 weeks) was 0.08 [99% CI: 0.00, 0.16].<h4>Conclusions</h4>First-trimester malaria was associated with increased prevalence of anemia later in pregnancy. We identified areas for further investigation including effects of first-trimester malaria on preterm birth and low birth weight. |
| format | Article |
| id | doaj-art-b71de5cab39b4876965b164d08c92050 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-b71de5cab39b4876965b164d08c920502025-01-08T05:32:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031033910.1371/journal.pone.0310339Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo.Sequoia I LeubaDaniel WestreichCarl L BoseAndrew F OlshanSteve M TaylorAntoinette TshefuAdrien LokangakaWaldemar A CarloElwyn ChombaMusaku MwenechanyaEdward A LiechtySherri L BucherOsayame A EkhaguereFabian EsamaiPaul NyongesaSaleem JessaniSarah SaleemRobert L GoldenbergJanet L MooreTracy L NolenJennifer Hemingway-FodayElizabeth M McClureMarion Koso-ThomasRichard J DermanMatthew HoffmanSteven R MeshnickMelissa Bauserman<h4>Background</h4>Few studies have assessed the impact of first-trimester malaria infection during pregnancy. We estimated this impact on adverse maternal and pregnancy outcomes.<h4>Methods</h4>In a convenience sample of women from the ASPIRIN (Aspirin Supplementation for Pregnancy Indicated risk Reduction In Nulliparas) trial in Kenya, Zambia, and the Democratic Republic of the Congo, we tested for first-trimester Plasmodium falciparum infection using quantitative polymerase chain reaction. We estimated site-specific effects on pregnancy outcomes using parametric g-computation.<h4>Results</h4>Compared to uninfected women, we observed the adjusted site-specific prevalence differences (PDs) among women with first-trimester malaria of the following pregnancy outcomes: preterm birth among Congolese (aPD = 0.06 [99% CI: -0.04, 0.16]), Kenyan (0.03 [-0.04, 0.09]), and Zambian (0.00 [-0.10, 0.20]) women; low birth weight among Congolese (0.07 [-0.03, 0.16]), Kenyan (0.01 [-0.04, 0.06]) and Zambian (-0.04 [-0.13, 0.16]) women; spontaneous abortion among Congolese (0.00 [-0.05, 0.04]), Kenyan (0.00 [-0.04, 0.04]), and Zambian (0.02 [-0.07, 0.24]) women, and anemia later in pregnancy among Congolese (0.04 [-0.09, 0.16]), Kenyan (0.05 [-0.06, 0.17]), and Zambian (0.07 [-0.12, 0.36]) women. The pooled PD for anemia later in pregnancy (26-30 weeks) was 0.08 [99% CI: 0.00, 0.16].<h4>Conclusions</h4>First-trimester malaria was associated with increased prevalence of anemia later in pregnancy. We identified areas for further investigation including effects of first-trimester malaria on preterm birth and low birth weight.https://doi.org/10.1371/journal.pone.0310339 |
| spellingShingle | Sequoia I Leuba Daniel Westreich Carl L Bose Andrew F Olshan Steve M Taylor Antoinette Tshefu Adrien Lokangaka Waldemar A Carlo Elwyn Chomba Musaku Mwenechanya Edward A Liechty Sherri L Bucher Osayame A Ekhaguere Fabian Esamai Paul Nyongesa Saleem Jessani Sarah Saleem Robert L Goldenberg Janet L Moore Tracy L Nolen Jennifer Hemingway-Foday Elizabeth M McClure Marion Koso-Thomas Richard J Derman Matthew Hoffman Steven R Meshnick Melissa Bauserman Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo. PLoS ONE |
| title | Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo. |
| title_full | Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo. |
| title_fullStr | Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo. |
| title_full_unstemmed | Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo. |
| title_short | Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo. |
| title_sort | effects on maternal and pregnancy outcomes of first trimester malaria infection among nulliparous women from kenya zambia and the democratic republic of the congo |
| url | https://doi.org/10.1371/journal.pone.0310339 |
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