Gene Therapy for Inflammatory Cascade in Intrauterine Injury with Engineered Extracellular Vesicles Hybrid Snail Mucus‐enhanced Adhesive Hydrogels

Gene Therapy for Inflammatory Cascade in Intrauterine Injury with Engineered Extracellular Vesicles Hybrid Snail Mucus‐enhanced Adhesive Hydrogels

Abstract Early hyper‐inflammation caused by intrauterine injury triggered subsequent intrauterine adhesion (IUA). STAT1‐mediated M1 macrophages are confirmed to secrete pro‐inflammatory cytokines to accelerate inflammatory cascade and IUA formation by multi‐omics analysis and experimental verificati...

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Bibliographic Details
Main Authors: Xiaotong Peng, Tao Wang, Bo Dai, Yiping Zhu, Mei Ji, Pusheng Yang, Jiaxin Zhang, Wenwen Liu, Yaxin Miao, Yonghang Liu, Shuo Wang, Jing Sun
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
adhesive hydrogels
extracellular vesicles
gene therapy
intrauterine adhesions
macrophage polarization
Online Access:https://doi.org/10.1002/advs.202410769
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