Effect of metformin on the clinical outcomes of stroke in patients with diabetes: a systematic review and meta-analysis
Objectives Stroke is a major cause of death and disability globally, especially among diabetic patients. In this study, we aim to scrutinise the effects of metformin on the clinical outcomes of stroke in diabetic patients.Design This study followed the Preferred Reporting Items for Systematic Review...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/1/e092214.full |
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| author | Jianming Zhu Jun Wen Zhihua Huang Jianyi Liu Fuqun Luo Yizhi Guo Yandeng Li |
| author_facet | Jianming Zhu Jun Wen Zhihua Huang Jianyi Liu Fuqun Luo Yizhi Guo Yandeng Li |
| author_sort | Jianming Zhu |
| collection | DOAJ |
| description | Objectives Stroke is a major cause of death and disability globally, especially among diabetic patients. In this study, we aim to scrutinise the effects of metformin on the clinical outcomes of stroke in diabetic patients.Design This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Data sources PubMed, Embase and Web of Science databases were searched between their inception and 5 December 2023.Eligibility criteria for selecting studies Studies investigating the effect of metformin on the clinical outcomes of stroke in patients with diabetes were included.Data extraction and synthesis The effect of metformin on the clinical outcomes of stroke in patients with diabetes was identified using combined ORs and 95% CIs.Results A total of 11 studies involving 18 525 participants were included in this review. Pooled analysis has demonstrated that prestroke metformin use could reduce the probability of poor course after stroke by 34% in diabetes mellitus (DM) patients (OR=0.66, 95% CI: 0.61 to 0.72) and reduce the probability of death by 43% (OR=0.57, 95% CI: 0.51 to 0.64).Conclusions Prestroke metformin use is beneficial for the improvement of clinical outcomes in patients who had a stroke with DM, although the potential bias should be carefully considered.PROSPERO registration number CRD42024496056. |
| format | Article |
| id | doaj-art-b6e75dbe30c04aa4af8b5adc45dc155f |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-b6e75dbe30c04aa4af8b5adc45dc155f2025-01-17T23:15:09ZengBMJ Publishing GroupBMJ Open2044-60552025-01-0115110.1136/bmjopen-2024-092214Effect of metformin on the clinical outcomes of stroke in patients with diabetes: a systematic review and meta-analysisJianming Zhu0Jun Wen1Zhihua Huang2Jianyi Liu3Fuqun Luo4Yizhi Guo5Yandeng Li61 Changde Hospital, Xiangya School of Medicine, Central South University (The First People`s Hospital of Changde City), Changde, Hunan, China1 Changde Hospital, Xiangya School of Medicine, Central South University (The First People`s Hospital of Changde City), Changde, Hunan, China1 Changde Hospital, Xiangya School of Medicine, Central South University (The First People`s Hospital of Changde City), Changde, Hunan, China1 Changde Hospital, Xiangya School of Medicine, Central South University (The First People`s Hospital of Changde City), Changde, Hunan, China1 Changde Hospital, Xiangya School of Medicine, Central South University (The First People`s Hospital of Changde City), Changde, Hunan, China1 Changde Hospital, Xiangya School of Medicine, Central South University (The First People`s Hospital of Changde City), Changde, Hunan, China2 Department of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People`s Hospital of Changde City), Changde, Hunan, ChinaObjectives Stroke is a major cause of death and disability globally, especially among diabetic patients. In this study, we aim to scrutinise the effects of metformin on the clinical outcomes of stroke in diabetic patients.Design This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Data sources PubMed, Embase and Web of Science databases were searched between their inception and 5 December 2023.Eligibility criteria for selecting studies Studies investigating the effect of metformin on the clinical outcomes of stroke in patients with diabetes were included.Data extraction and synthesis The effect of metformin on the clinical outcomes of stroke in patients with diabetes was identified using combined ORs and 95% CIs.Results A total of 11 studies involving 18 525 participants were included in this review. Pooled analysis has demonstrated that prestroke metformin use could reduce the probability of poor course after stroke by 34% in diabetes mellitus (DM) patients (OR=0.66, 95% CI: 0.61 to 0.72) and reduce the probability of death by 43% (OR=0.57, 95% CI: 0.51 to 0.64).Conclusions Prestroke metformin use is beneficial for the improvement of clinical outcomes in patients who had a stroke with DM, although the potential bias should be carefully considered.PROSPERO registration number CRD42024496056.https://bmjopen.bmj.com/content/15/1/e092214.full |
| spellingShingle | Jianming Zhu Jun Wen Zhihua Huang Jianyi Liu Fuqun Luo Yizhi Guo Yandeng Li Effect of metformin on the clinical outcomes of stroke in patients with diabetes: a systematic review and meta-analysis BMJ Open |
| title | Effect of metformin on the clinical outcomes of stroke in patients with diabetes: a systematic review and meta-analysis |
| title_full | Effect of metformin on the clinical outcomes of stroke in patients with diabetes: a systematic review and meta-analysis |
| title_fullStr | Effect of metformin on the clinical outcomes of stroke in patients with diabetes: a systematic review and meta-analysis |
| title_full_unstemmed | Effect of metformin on the clinical outcomes of stroke in patients with diabetes: a systematic review and meta-analysis |
| title_short | Effect of metformin on the clinical outcomes of stroke in patients with diabetes: a systematic review and meta-analysis |
| title_sort | effect of metformin on the clinical outcomes of stroke in patients with diabetes a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/15/1/e092214.full |
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