Effect of Vitamin E versus Vitamin C Application on Wound Healing in the Gingival Depigmentation Procedure: A Split-mouth Clinical Comparative Study

Aim: The aim of this study was to evaluate the clinical efficacy of Vitamin E and C application on healing after the gingival depigmentation (GD) procedure. Materials and Methods: A split-mouth study was planned for subjects with gingival melanin hyperpigmentation in maxillary and/or mandibular arch...

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Main Authors: Ritu Agrawal, Shailendra Chauhan, Aditya Sinha, Satendra Sharma, Gaurav Singh, Ankita Garg
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:Dentistry and Medical Research
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Online Access:https://journals.lww.com/10.4103/dmr.dmr_41_23
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Summary:Aim: The aim of this study was to evaluate the clinical efficacy of Vitamin E and C application on healing after the gingival depigmentation (GD) procedure. Materials and Methods: A split-mouth study was planned for subjects with gingival melanin hyperpigmentation in maxillary and/or mandibular arches. Each site was randomly divided into two groups. The scalpel surgical technique for depigmentation was performed under local anesthesia. After the depigmentation procedure, Vitamin E was applied in Group 1, and Vitamin C was applied in Group 2. The healing index and Visual Analog Scale scores for pain were recorded on the 15th day and the 45th day postoperatively. Results: There was a statistically significant reduction in Visual Analog Scale scores and improvement in healing in both groups on the 15th day. Subjects in the Vitamin E showed better healing and reduced pain on the 15th day as compared to Vitamin C, but at the 45th day, there was no significant difference in both groups. Conclusion: Subjects would show faster healing with the use of Vitamin E application after the surgical procedure of GD.
ISSN:2348-1471