Brain network correlates of affective symptoms in aMCI
Affective symptoms (i.e., depression, anxiety, and apathy) are the most prevalent subsyndrome of neuropsychiatric symptoms (NPS) in preclinical dementia, such as amnestic mild cognitive impairment (aMCI), and remain a challenge to understand and treat. The distressing nature of these symptoms and co...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Aging Brain |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589958924000227 |
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| author | Parnika P. Saxena Adam Turnbull Daniel Kim Barbara Sommer F. Vankee Lin |
| author_facet | Parnika P. Saxena Adam Turnbull Daniel Kim Barbara Sommer F. Vankee Lin |
| author_sort | Parnika P. Saxena |
| collection | DOAJ |
| description | Affective symptoms (i.e., depression, anxiety, and apathy) are the most prevalent subsyndrome of neuropsychiatric symptoms (NPS) in preclinical dementia, such as amnestic mild cognitive impairment (aMCI), and remain a challenge to understand and treat. The distressing nature of these symptoms and complexity of their concurrence and interaction necessitates improved understanding of their underlying neural correlates. We analyzed the relationships between functional brain topology (i.e., the way the brain’s functional network is organized to allow efficient communication between regions) and affective symptoms in aMCI using cross-sectional and longitudinal methods. The analyses demonstrated that increased clustering coefficient (CC) was related to lower baseline and greater decreases in affective symptoms, while higher participation coefficient (PC) was correlated with more severe baseline affective symptoms. These findings suggest that the brain losing the capacity to form segregated functional units may be related to prevalence and severity of affective symptoms seen in aMCI. |
| format | Article |
| id | doaj-art-b6d685e4095e4ce0996510c7f9661831 |
| institution | Kabale University |
| issn | 2589-9589 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aging Brain |
| spelling | doaj-art-b6d685e4095e4ce0996510c7f96618312024-12-08T06:11:55ZengElsevierAging Brain2589-95892024-01-016100126Brain network correlates of affective symptoms in aMCIParnika P. Saxena0Adam Turnbull1Daniel Kim2Barbara Sommer3F. Vankee Lin4Department of Psychiatry and Behavioral Sciences, Stanford University, USACorresponding author.; Department of Psychiatry and Behavioral Sciences, Stanford University, USADepartment of Psychiatry and Behavioral Sciences, Stanford University, USADepartment of Psychiatry and Behavioral Sciences, Stanford University, USADepartment of Psychiatry and Behavioral Sciences, Stanford University, USAAffective symptoms (i.e., depression, anxiety, and apathy) are the most prevalent subsyndrome of neuropsychiatric symptoms (NPS) in preclinical dementia, such as amnestic mild cognitive impairment (aMCI), and remain a challenge to understand and treat. The distressing nature of these symptoms and complexity of their concurrence and interaction necessitates improved understanding of their underlying neural correlates. We analyzed the relationships between functional brain topology (i.e., the way the brain’s functional network is organized to allow efficient communication between regions) and affective symptoms in aMCI using cross-sectional and longitudinal methods. The analyses demonstrated that increased clustering coefficient (CC) was related to lower baseline and greater decreases in affective symptoms, while higher participation coefficient (PC) was correlated with more severe baseline affective symptoms. These findings suggest that the brain losing the capacity to form segregated functional units may be related to prevalence and severity of affective symptoms seen in aMCI.http://www.sciencedirect.com/science/article/pii/S2589958924000227 |
| spellingShingle | Parnika P. Saxena Adam Turnbull Daniel Kim Barbara Sommer F. Vankee Lin Brain network correlates of affective symptoms in aMCI Aging Brain |
| title | Brain network correlates of affective symptoms in aMCI |
| title_full | Brain network correlates of affective symptoms in aMCI |
| title_fullStr | Brain network correlates of affective symptoms in aMCI |
| title_full_unstemmed | Brain network correlates of affective symptoms in aMCI |
| title_short | Brain network correlates of affective symptoms in aMCI |
| title_sort | brain network correlates of affective symptoms in amci |
| url | http://www.sciencedirect.com/science/article/pii/S2589958924000227 |
| work_keys_str_mv | AT parnikapsaxena brainnetworkcorrelatesofaffectivesymptomsinamci AT adamturnbull brainnetworkcorrelatesofaffectivesymptomsinamci AT danielkim brainnetworkcorrelatesofaffectivesymptomsinamci AT barbarasommer brainnetworkcorrelatesofaffectivesymptomsinamci AT fvankeelin brainnetworkcorrelatesofaffectivesymptomsinamci |