The role and therapeutic value of NUSAP1 in human cancers
Abstract In recent years, the incidence of cancer has increased, and early diagnosis and treatment are key to cancer treatment. Nucleolar and spindle-associated protein 1 (NUSAP1) is a crucial mitotic regulator. NUSAP1 binds to microtubules and mediates their attachment to chromosomes, ensuring the...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06746-2 |
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| author | Shenyuan Xu Ding Nan Ruiqi Liu Chenting Liu Yuefeng Hu Luanluan Huang Xiaoyan Chen Hailong Sheng Yanwei Lu Haibo Zhang |
| author_facet | Shenyuan Xu Ding Nan Ruiqi Liu Chenting Liu Yuefeng Hu Luanluan Huang Xiaoyan Chen Hailong Sheng Yanwei Lu Haibo Zhang |
| author_sort | Shenyuan Xu |
| collection | DOAJ |
| description | Abstract In recent years, the incidence of cancer has increased, and early diagnosis and treatment are key to cancer treatment. Nucleolar and spindle-associated protein 1 (NUSAP1) is a crucial mitotic regulator. NUSAP1 binds to microtubules and mediates their attachment to chromosomes, ensuring the accurate distribution of genetic material to the two daughter cells. NUSAP1 is located on chromosome 15q15.1 and is typically expressed in proliferating cells, suggesting a potential oncogenic role. Studies have shown that NUSAP1 plays a significant role in various cancers, including breast cancer, cervical cancer, lung cancer, prostate cancer, and hepatocellular carcinoma. Furthermore, NUSAP1 may serve as a promising biomarker for cancer diagnosis and prognosis. In this review, we discuss the roles and mechanisms of NUSAP1 in human cancers. |
| format | Article |
| id | doaj-art-b6d03a8ed2c44d6ea7bc0b0ffdea3ae1 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-b6d03a8ed2c44d6ea7bc0b0ffdea3ae12025-08-20T03:37:41ZengBMCJournal of Translational Medicine1479-58762025-07-0123111810.1186/s12967-025-06746-2The role and therapeutic value of NUSAP1 in human cancersShenyuan Xu0Ding Nan1Ruiqi Liu2Chenting Liu3Yuefeng Hu4Luanluan Huang5Xiaoyan Chen6Hailong Sheng7Yanwei Lu8Haibo Zhang9Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeDepartment of Pathology, Tongde Hospital of Zhejiang ProvinceCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeCancer Center, Department of Radiation Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical CollegeAbstract In recent years, the incidence of cancer has increased, and early diagnosis and treatment are key to cancer treatment. Nucleolar and spindle-associated protein 1 (NUSAP1) is a crucial mitotic regulator. NUSAP1 binds to microtubules and mediates their attachment to chromosomes, ensuring the accurate distribution of genetic material to the two daughter cells. NUSAP1 is located on chromosome 15q15.1 and is typically expressed in proliferating cells, suggesting a potential oncogenic role. Studies have shown that NUSAP1 plays a significant role in various cancers, including breast cancer, cervical cancer, lung cancer, prostate cancer, and hepatocellular carcinoma. Furthermore, NUSAP1 may serve as a promising biomarker for cancer diagnosis and prognosis. In this review, we discuss the roles and mechanisms of NUSAP1 in human cancers.https://doi.org/10.1186/s12967-025-06746-2NUSAP1CancerDiagnosisBiomarker |
| spellingShingle | Shenyuan Xu Ding Nan Ruiqi Liu Chenting Liu Yuefeng Hu Luanluan Huang Xiaoyan Chen Hailong Sheng Yanwei Lu Haibo Zhang The role and therapeutic value of NUSAP1 in human cancers Journal of Translational Medicine NUSAP1 Cancer Diagnosis Biomarker |
| title | The role and therapeutic value of NUSAP1 in human cancers |
| title_full | The role and therapeutic value of NUSAP1 in human cancers |
| title_fullStr | The role and therapeutic value of NUSAP1 in human cancers |
| title_full_unstemmed | The role and therapeutic value of NUSAP1 in human cancers |
| title_short | The role and therapeutic value of NUSAP1 in human cancers |
| title_sort | role and therapeutic value of nusap1 in human cancers |
| topic | NUSAP1 Cancer Diagnosis Biomarker |
| url | https://doi.org/10.1186/s12967-025-06746-2 |
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