LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK

LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK

Objective: Loss of functional β-cell mass is a major cause of diabetes. Thus, identifying regulators of β-cell health is crucial for treating this disease. The Leucine-rich repeat-containing G-protein-coupled receptor (GPCR) 4 (LGR4) is expressed in β-cells and is the fourth most abundant GPCR in hu...

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Main Authors: Joanna Filipowska, Zelda Cisneros, Sneha S. Varghese, Nancy Leon-Rivera, Peng Wang, Randy Kang, Geming Lu, Yate-Ching Yuan, Hung-Ping Shih, Supriyo Bhattacharya, Sangeeta Dhawan, Adolfo Garcia-Ocaña, Nagesha Guthalu Kondegowda, Rupangi C. Vasavada
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Molecular Metabolism
Subjects:
LGR4
β-cell stress
RANK
NFκB
β-cell proliferation
β-cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000043
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