Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study
IntroductionCognitive symptoms are common in Parkinson's Disease (PD), and digital interventions like telerehabilitation other an accessible way to manage these symptoms. This study aimed to assess the effectiveness of a Home-Based Computerized Cognitive Training (HB-CCT) program in individuals...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2024.1531688/full |
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| author | Serena Tagliente Brigida Minafra Simona Aresta Simona Aresta Paola Santacesaria Andrea Buccoliero Cinzia Palmirotta Gianvito Lagravinese Davide Mongelli Christian Gelao Luigi Macchitella Stefania Pazzi Domenico Scrutinio Paola Baiardi Petronilla Battista |
| author_facet | Serena Tagliente Brigida Minafra Simona Aresta Simona Aresta Paola Santacesaria Andrea Buccoliero Cinzia Palmirotta Gianvito Lagravinese Davide Mongelli Christian Gelao Luigi Macchitella Stefania Pazzi Domenico Scrutinio Paola Baiardi Petronilla Battista |
| author_sort | Serena Tagliente |
| collection | DOAJ |
| description | IntroductionCognitive symptoms are common in Parkinson's Disease (PD), and digital interventions like telerehabilitation other an accessible way to manage these symptoms. This study aimed to assess the effectiveness of a Home-Based Computerized Cognitive Training (HB-CCT) program in individuals with PD using a pilot randomized cross-over design.MethodsTwenty-five participants (mean age 69.32 ± 7.21 years, mean MDS-UPDRS III 33.76 ± 14.25) with PD and mild cognitive impairment were enrolled. They underwent neuropsychological assessments at three time points (5-week intervals): Baseline, after the HB-CCTi, and after Standard Care. The HB-CCT consisted of the Neurotablet® platform that was used to target cognitive domains such as Attention, Memory, Perception, Executive Functioning and Language. All participants completed both the Neurotablet intervention and Standard Care blocks in a randomized order. After a Shapiro-Wilk test, non-parametric repeated measures analyses of variance (Friedman's test) and post-hoc comparisons corrected with the Benjamini-Hochberg approach were performed to compare the effects on primary and secondary cognitive outcomes over experimental intervention and Standard Care.ResultsThe results from the Friedman analysis revealed significant improvements in Word List Immediate Recall, Digit Span Forward and Complex Figure Recall (all p < 0.001) following the HB-CCT, compared to the Baseline. Additionally, Naming performance showed significant improvement after the HB-CCT (p = 0.02). Significant differences were also observed when comparing the HB-CCT with Standard Care, with improved performance in TMT-A (p = 0.02), Phonemic Fluency (p < 0.01), and Digit Span Forward (p < 0.01).DiscussionThese findings suggest that HB-CCT via Neurotablet can effectively enhance specific cognitive abilities in PD, supporting the role of digital, home-based interventions as feasible strategies to mitigate cognitive decline. |
| format | Article |
| id | doaj-art-b6ae356e4d734301afed471459992ff7 |
| institution | Kabale University |
| issn | 1664-1078 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychology |
| spelling | doaj-art-b6ae356e4d734301afed471459992ff72025-01-09T06:10:08ZengFrontiers Media S.A.Frontiers in Psychology1664-10782025-01-011510.3389/fpsyg.2024.15316881531688Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over studySerena Tagliente0Brigida Minafra1Simona Aresta2Simona Aresta3Paola Santacesaria4Andrea Buccoliero5Cinzia Palmirotta6Gianvito Lagravinese7Davide Mongelli8Christian Gelao9Luigi Macchitella10Stefania Pazzi11Domenico Scrutinio12Paola Baiardi13Petronilla Battista14Istituti Clinici Scientifici Maugeri IRCCS, Laboratory of Neuropsychology of Bari Institute, Bari, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation Unit of Bari Institute, Bari, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Laboratory of Neuropsychology of Bari Institute, Bari, ItalyUniversity School for Advanced Studies IUSS Pavia, Pavia, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Laboratory of Neuropsychology of Bari Institute, Bari, ItalyR&D Department GPI SpA, Università degli Studi di Verona, Verona, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Laboratory of Neuropsychology of Bari Institute, Bari, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Laboratory of Neuropsychology of Bari Institute, Bari, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Laboratory of Neuropsychology of Bari Institute, Bari, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Neurorehabilitation Unit of Bari Institute, Bari, ItalyUnit for Severe Disabilities in Developmental Age and Young Adults (Developmental Neurology and Neurorehabilitation), Associazione “La Nostra Famiglia” - IRCCS “E. Medea”, Scientific Hospital for Neurorehabilitation, Brindisi, ItalyUnit for Severe Disabilities in Developmental Age and Young Adults (Developmental Neurology and Neurorehabilitation), Associazione “La Nostra Famiglia” - IRCCS “E. Medea”, Scientific Hospital for Neurorehabilitation, Brindisi, ItalyConsorzio di Bioingegneria e Informatica Medica (CBIM), Pavia, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Direzione Scientifica Centrale of Pavia Institute, Pavia, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Laboratory of Neuropsychology of Bari Institute, Bari, ItalyIntroductionCognitive symptoms are common in Parkinson's Disease (PD), and digital interventions like telerehabilitation other an accessible way to manage these symptoms. This study aimed to assess the effectiveness of a Home-Based Computerized Cognitive Training (HB-CCT) program in individuals with PD using a pilot randomized cross-over design.MethodsTwenty-five participants (mean age 69.32 ± 7.21 years, mean MDS-UPDRS III 33.76 ± 14.25) with PD and mild cognitive impairment were enrolled. They underwent neuropsychological assessments at three time points (5-week intervals): Baseline, after the HB-CCTi, and after Standard Care. The HB-CCT consisted of the Neurotablet® platform that was used to target cognitive domains such as Attention, Memory, Perception, Executive Functioning and Language. All participants completed both the Neurotablet intervention and Standard Care blocks in a randomized order. After a Shapiro-Wilk test, non-parametric repeated measures analyses of variance (Friedman's test) and post-hoc comparisons corrected with the Benjamini-Hochberg approach were performed to compare the effects on primary and secondary cognitive outcomes over experimental intervention and Standard Care.ResultsThe results from the Friedman analysis revealed significant improvements in Word List Immediate Recall, Digit Span Forward and Complex Figure Recall (all p < 0.001) following the HB-CCT, compared to the Baseline. Additionally, Naming performance showed significant improvement after the HB-CCT (p = 0.02). Significant differences were also observed when comparing the HB-CCT with Standard Care, with improved performance in TMT-A (p = 0.02), Phonemic Fluency (p < 0.01), and Digit Span Forward (p < 0.01).DiscussionThese findings suggest that HB-CCT via Neurotablet can effectively enhance specific cognitive abilities in PD, supporting the role of digital, home-based interventions as feasible strategies to mitigate cognitive decline.https://www.frontiersin.org/articles/10.3389/fpsyg.2024.1531688/fullrehabilitationtelerehabilitationcognitive trainingneuropsychologyPD |
| spellingShingle | Serena Tagliente Brigida Minafra Simona Aresta Simona Aresta Paola Santacesaria Andrea Buccoliero Cinzia Palmirotta Gianvito Lagravinese Davide Mongelli Christian Gelao Luigi Macchitella Stefania Pazzi Domenico Scrutinio Paola Baiardi Petronilla Battista Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study Frontiers in Psychology rehabilitation telerehabilitation cognitive training neuropsychology PD |
| title | Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study |
| title_full | Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study |
| title_fullStr | Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study |
| title_full_unstemmed | Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study |
| title_short | Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study |
| title_sort | effectiveness of a home based computerized cognitive training in parkinson s disease a pilot randomized cross over study |
| topic | rehabilitation telerehabilitation cognitive training neuropsychology PD |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2024.1531688/full |
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