Research progress on the mechanism of propofol in regulating autophagy
Autophagy is a process in which intracellular lysosomes are involved in the degradation of damaged organelles or macromolecular substances. In the physiological state, eukaryotic cells maintain tissue homeostasis through a low degree of autophagy. In recent years, many studies have shown that autoph...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of New Medicine
2023-02-01
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| Series: | Yixue xinzhi zazhi |
| Subjects: | |
| Online Access: | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2302/edVsL1ONno0trp1qWpLhaTpCUf336G2bFFyJ0eDM.pdf |
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| Summary: | Autophagy is a process in which intracellular lysosomes are involved in the degradation of damaged organelles or macromolecular substances. In the physiological state, eukaryotic cells maintain tissue homeostasis through a low degree of autophagy. In recent years, many studies have shown that autophagy is involved in the pathophysiological disease processes caused by ischemia and hypoxia. As a commonly used intravenous an-esthetic, propofol is widely used in various types of surgery. Recent studies have shown that propofol plays a protective role by inhibiting autophagic cell death induced by ische-mia/reperfusion and hypoxia/reoxygenation. Meanwhile, other studies have shown that propofol can activate autophagy and have an anti-tumor effect. Current studies on the regulation of autophagy by propofol, involve AMPK/mTOR, Bcl/Beclin, Ca2+, miRNA and other cell signaling pathways. Based on the latest research, this paper reviews the mechanisms of propofol regulation of autophagy. |
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| ISSN: | 1004-5511 |