Association of altered cortical gyrification and working memory in male early abstinent alcohol-dependent individuals
Background: Alcohol dependence (AD) is an addictive disorder with multifaceted neurobiological features. Recent research on the pathophysiological mechanisms of AD has emphasized the important role of dysconnectivity. Cortical gyrification is known to be a reliable marker of neural connectivity. Thi...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923024003009 |
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| author | Hai-ling Cao Wei Wei Ya-jing Meng Yu-jie Tao Xia Yang Tao Li Wan-jun Guo |
| author_facet | Hai-ling Cao Wei Wei Ya-jing Meng Yu-jie Tao Xia Yang Tao Li Wan-jun Guo |
| author_sort | Hai-ling Cao |
| collection | DOAJ |
| description | Background: Alcohol dependence (AD) is an addictive disorder with multifaceted neurobiological features. Recent research on the pathophysiological mechanisms of AD has emphasized the important role of dysconnectivity. Cortical gyrification is known to be a reliable marker of neural connectivity. This study aimed to explore cortical gyrification using the local gyrification index (LGI) between alcohol-dependent patients and controls. Methods: Magnetic resonance images were collected from 60 early abstinent patients with AD (5–12 days after stopping alcohol consumption) and 59 controls and preprocessed using FreeSurfer, followed by surface-based morphometry (SBM) analysis to compare the LGI between the two groups. Cognitive performance was assessed using the Spatial Working Memory (SWM) test in the Cambridge Neuropsychological Test Automated Battery (CANTAB). The relationship between LGI, cognitive performance, and clinical variables was also explored in the patient group. Results: Compared with controls, patients with AD exhibited significantly decreased LGI in several regions, including the postcentral gyrus, precentral gyrus, middle frontal, superior temporal, middle temporal, insula, superior parietal, and inferior parietal cortex. AD patients did worse than controls in several SWM measures. Furthermore, decreased LGI in the left postcentral was negatively correlated with working memory performance after multiple comparison corrections in the patient group. Conclusion: Alcohol-dependent individuals exhibit abnormal patterns of cortical gyrification, which may be underlying neurobiological markers of AD. Our findings further indicate that working memory deficits may be related to abnormalities in cortical gyrification in alcohol addiction. |
| format | Article |
| id | doaj-art-b6a08ddace9244999e6e9692cac2f592 |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-b6a08ddace9244999e6e9692cac2f5922025-01-10T04:37:02ZengElsevierBrain Research Bulletin1873-27472025-01-01220111166Association of altered cortical gyrification and working memory in male early abstinent alcohol-dependent individualsHai-ling Cao0Wei Wei1Ya-jing Meng2Yu-jie Tao3Xia Yang4Tao Li5Wan-jun Guo6Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou 310063, ChinaMental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaMental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaMental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, ChinaDepartment of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou 310063, China; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, 1369 West Wenyi Road, Hangzhou 311121, ChinaMental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou 310063, China; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, 1369 West Wenyi Road, Hangzhou 311121, China; Corresponding author at: Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou 310063, China.Background: Alcohol dependence (AD) is an addictive disorder with multifaceted neurobiological features. Recent research on the pathophysiological mechanisms of AD has emphasized the important role of dysconnectivity. Cortical gyrification is known to be a reliable marker of neural connectivity. This study aimed to explore cortical gyrification using the local gyrification index (LGI) between alcohol-dependent patients and controls. Methods: Magnetic resonance images were collected from 60 early abstinent patients with AD (5–12 days after stopping alcohol consumption) and 59 controls and preprocessed using FreeSurfer, followed by surface-based morphometry (SBM) analysis to compare the LGI between the two groups. Cognitive performance was assessed using the Spatial Working Memory (SWM) test in the Cambridge Neuropsychological Test Automated Battery (CANTAB). The relationship between LGI, cognitive performance, and clinical variables was also explored in the patient group. Results: Compared with controls, patients with AD exhibited significantly decreased LGI in several regions, including the postcentral gyrus, precentral gyrus, middle frontal, superior temporal, middle temporal, insula, superior parietal, and inferior parietal cortex. AD patients did worse than controls in several SWM measures. Furthermore, decreased LGI in the left postcentral was negatively correlated with working memory performance after multiple comparison corrections in the patient group. Conclusion: Alcohol-dependent individuals exhibit abnormal patterns of cortical gyrification, which may be underlying neurobiological markers of AD. Our findings further indicate that working memory deficits may be related to abnormalities in cortical gyrification in alcohol addiction.http://www.sciencedirect.com/science/article/pii/S0361923024003009Alcohol dependenceCortical gyrificationLocal gyrification indexWorking memoryCognitive performance |
| spellingShingle | Hai-ling Cao Wei Wei Ya-jing Meng Yu-jie Tao Xia Yang Tao Li Wan-jun Guo Association of altered cortical gyrification and working memory in male early abstinent alcohol-dependent individuals Brain Research Bulletin Alcohol dependence Cortical gyrification Local gyrification index Working memory Cognitive performance |
| title | Association of altered cortical gyrification and working memory in male early abstinent alcohol-dependent individuals |
| title_full | Association of altered cortical gyrification and working memory in male early abstinent alcohol-dependent individuals |
| title_fullStr | Association of altered cortical gyrification and working memory in male early abstinent alcohol-dependent individuals |
| title_full_unstemmed | Association of altered cortical gyrification and working memory in male early abstinent alcohol-dependent individuals |
| title_short | Association of altered cortical gyrification and working memory in male early abstinent alcohol-dependent individuals |
| title_sort | association of altered cortical gyrification and working memory in male early abstinent alcohol dependent individuals |
| topic | Alcohol dependence Cortical gyrification Local gyrification index Working memory Cognitive performance |
| url | http://www.sciencedirect.com/science/article/pii/S0361923024003009 |
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